2-bromo-1-(3,4-dimethoxy-phenyl)-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-1-(3,4-dimethoxy-phenyl)-ethanol
• 英文别名: 2-Brom-1-(3,4-dimethoxy-phenyl)-aethanol；1²-Brom-1¹-oxy-3.4-dimethoxy-1-aethyl-benzol；β-Brom-α-(3.4-dimethoxy-phenyl)-aethylalkohol；Brommethyl-(3.4-dimethoxy-phenyl)-carbinol；2-Bromo-1-(3,4-dimethoxyphenyl)ethan-1-ol；2-bromo-1-(3,4-dimethoxyphenyl)ethanol
• 化学式: C₁₀H₁₃BrO₃
• 分子量: 261.115
• InChiKey: VAXOJZZUVFJONX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromo-1-(3,4-dimethoxy-phenyl)-ethanol 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 1.0h， 生成 2-(3,4-二甲氧基苯基)环氧乙烷
  参考文献：
  名称：

  Rh–IndOlefOx catalyzed conjugate addition/Heck-type coupling of organoboronics to a lactam or a lactone

  摘要：

  Four indole-olefin-oxazoline (IndOlefOx) ligands were synthesized and evaluated in Rh-catalyzed reactions between organoboronics and a lactam or a lactone. In addition to the expected conjugate addition products, the formation of significant amounts of Heck-type products was observed. The scope and limitations of these reactions were investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.040
• 作为产物：
  描述：

  溴代-3,4-二甲氧基苯乙酮 在 sodium tetrahydroborate 、 盐酸 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 0.25h， 生成 2-bromo-1-(3,4-dimethoxy-phenyl)-ethanol
  参考文献：
  名称：

  Rh–IndOlefOx catalyzed conjugate addition/Heck-type coupling of organoboronics to a lactam or a lactone

  摘要：

  Four indole-olefin-oxazoline (IndOlefOx) ligands were synthesized and evaluated in Rh-catalyzed reactions between organoboronics and a lactam or a lactone. In addition to the expected conjugate addition products, the formation of significant amounts of Heck-type products was observed. The scope and limitations of these reactions were investigated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.040

文献信息

• 2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US04528194A1

  公开（公告）日：1985-07-09

  A piperazine derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydroxyl group, an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; R.sup.3 is a hydrogen atom, or an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; and R.sup.4 is a hydrogen atom or a lower alkoxy group containing 1-5 carbon atoms, provided that R.sup.2 is a group other than the lower alkoxy group containing 1-5 carbon atoms when both R.sup.3 and R.sup.4 are hydrogen atoms; or a pharmaceutically acceptable salt is effectively useful as a cerebral circulation-improving agent.

  化合物为哌嗪衍生物，其化学式为：##STR1##其中，R.sup.1为氢原子或低碳基烷基；R.sup.2为羟基、芳基烷氧基、含1-5个碳原子的低碳基烷氧基或含3-5个碳原子的低碳基烯氧基；R.sup.3为氢原子、芳基烷氧基、含1-5个碳原子的低碳基烷氧基或含3-5个碳原子的低碳基烯氧基；R.sup.4为氢原子或含1-5个碳原子的低碳基烷氧基，但当R.sup.3和R.sup.4均为氢原子时，R.sup.2为除含1-5个碳原子的低碳基烷氧基以外的基团；或其药学上可接受的盐可有效用作改善脑循环的药物。
• Barger; Jowett, Journal of the Chemical Society, 1905, vol. 87, p. 973
  作者：Barger、Jowett

  DOI：——

  日期：——
• Mannich, Archiv der Pharmazie, 1910, vol. 248, p. 143
  作者：Mannich

  DOI：——

  日期：——
• Chemical and Pharmaceutical Bulletin. 1995, 43, 241-246
  作者：

  DOI：——

  日期：——
• Rh–IndOlefOx catalyzed conjugate addition/Heck-type coupling of organoboronics to a lactam or a lactone
  作者：Noora Kuuloja、Matti Vaismaa、Robert Franzén

  DOI：10.1016/j.tet.2012.01.040

  日期：2012.3

  Four indole-olefin-oxazoline (IndOlefOx) ligands were synthesized and evaluated in Rh-catalyzed reactions between organoboronics and a lactam or a lactone. In addition to the expected conjugate addition products, the formation of significant amounts of Heck-type products was observed. The scope and limitations of these reactions were investigated. (C) 2012 Elsevier Ltd. All rights reserved.