(E)-N-[6-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)hexyl]-3-pyridin-3-ylprop-2-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (E)-N-[6-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)hexyl]-3-pyridin-3-ylprop-2-enamide
• 化学式: C₂₈H₃₁N₃O
• 分子量: 425.574
• InChiKey: VSAQSCYWJXCIDV-OBGWFSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME
  申请人：THE TRUSTEES OF INDIANA UNIVERSITY

  公开号：US20210070784A1

  公开（公告）日：2021-03-11

  Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase (“NAMPT”), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension (“PAH”). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
• [EN] NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME<br/>[FR] INHIBITEURS DE LA NICOTINAMIDE PHOSPHORIBOSYLTRANSFÉRASE ET MÉTHODES D'UTILISATION DE CEUX-CI
  申请人：THE BOARO OF TRUSTEES OF THE UNIV OF ILLINOIS

  公开号：WO2019153007A2

  公开（公告）日：2019-08-08

  Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase ("NAMPT"), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension ("PAH"). The compounds described herein can include compounds of Formula (II) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.