6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methyl-2(1H)-quinolinone | 439906-17-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methyl-2(1H)-quinolinone
• 英文别名: 6-[Amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methylquinolin-2-one
• CAS: 439906-17-9
• 化学式: C₂₉H₂₆Cl₂N₄O
• 分子量: 517.458
• InChiKey: VKDTXZIPYKSQHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2,2-Trichloroethyl-carbonochloridic acid ester 、 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methyl-2(1H)-quinolinone 生成 N'-[(Z)-(4-chlorophenyl)[4-[2-(3-chlorophenyl)ethyl]-1,2-dihydro-1-methyl-2-oxo-6-quinolinyl](1-methyl-1H-imidazol-5-yl)methyl]-N,N-dimethyl-methanimidamide
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  6-[chloro(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methyl-2(1H)-quinolinone 、 B₃A 、 NH₃/2-propanol 生成 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-[2-(3-chlorophenyl)ethyl]-1-methyl-2(1H)-quinolinone
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives
  申请人：——

  公开号：US20040063944A1

  公开（公告）日：2004-04-01

  This invention comprises the novel compounds of formula (I) 1 wherein r, s, t, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  这项发明涵盖了具有法尼西基转移酶抑制活性的式(I)1的新化合物，其中r、s、t、Y1、Y2、Z、R1、R2、R3、R4、R5、R6和R7具有定义的含义；它们的制备、含有它们的组合物以及它们作为药物的用途。
• FARNESYL TRANSFERASE INHIBITING 4-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1347966B1

  公开（公告）日：2006-03-08
• US7129356B2
  申请人：——

  公开号：US7129356B2

  公开（公告）日：2006-10-31
• [EN] FARNESYL TRANSFERASE INHIBITING 4-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES<br/>[FR] QUINOLINE 4-SUBSTITUEE INHIBITRICE DE LA TRANSFERASE FARNESYL ET DERIVES DE QUINAZOLINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2002051835A1

  公开（公告）日：2002-07-04

  This invention comprises the novel compounds of formula (I) wherein r, s, t, Y?1,Y2, Z, R1, R2, R3, R4, R5, R6 and R7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.