3-Acetoxy-cumarin | 58983-26-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-Acetoxy-cumarin
• 英文别名: 3-acetoxy-chromen-2-one；3-acetoxycoumarin；(2-oxochromen-3-yl) Acetate
• CAS: 58983-26-9
• 化学式: C₁₁H₈O₄
• 分子量: 204.182
• InChiKey: HVKRUWRASUGNHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Photo-caged fluorescent molecules
  申请人：Li Wen-Hong

  公开号：US20050042662A1

  公开（公告）日：2005-02-24

  A class of photo-caged and cell permeable fluorescent molecules having high uncaging cross sections, robust fluorescence enhancement, and flexible chemistry for bioconjugation. Some of the photo-caged fluorescent molecules are derived from 6-chloro-7-hydroxy-coumarin 3-carboxamide. The fluorescent molecules are useful for cellular imaging applications and particularly for tracing the molecular transfer between cellular gap junctions. The fluorescent molecules also have an emission wavelength that spectrally complements with the emission wavelength of other fluorophores, enabling simultaneous multi-color imaging.

  一类具有高解离交叉截面、稳健荧光增强和灵活化学结构以用于生物共轭的光解禁和细胞渗透性荧光分子。其中一些光解禁荧光分子源自6-氯-7-羟基香豆素-3-羧酰胺。这些荧光分子适用于细胞成像应用，特别适用于追踪细胞间隙连接的分子传输。这些荧光分子还具有发射波长，与其他荧光物质的发射波长光谱互补，实现同时多色成像。
• Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors
  申请人：——

  公开号：US20030224473A1

  公开（公告）日：2003-12-04

  The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes.

  本发明涉及一种用于测试样品中组蛋白去乙酰化酶酶活性的新方法。本发明还涉及一种筛选组蛋白去乙酰化酶酶抑制剂的新方法。
• Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
  申请人：——

  公开号：US20020115641A1

  公开（公告）日：2002-08-22

  Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.

  本发明公开了用于增强受试者吸收部位旁细胞渗透性的组合物和方法。该方法包括(a) 在需要增强细胞旁通透性时，向受试者施用有效量的磷脂酶 C 抑制剂；以及 (b) 通过施用有效量的磷脂酶 C 抑制剂，增强受试者吸收部位的细胞旁通透性。所公开的组合物和方法可增强受试者对亲水性药物的吸收。
• COMPOSITIONS AND METHODS FOR ENHANCING PARACELLULAR PERMEABILITY ACROSS EPITHELIAL AND ENDOTHELIAL BARRIERS
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1379235B1

  公开（公告）日：2006-12-20
• Compositions comprising phospholipase c inhibitors and methods for enhancing paracellular permeability across epithelial and endothelial barriers
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1754480B1

  公开（公告）日：2011-01-26