2,3,4,5-tetramethyl-benzoic acid amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4,5-tetramethyl-benzoic acid amide
• 英文别名: 2,3,4,5-Tetramethyl-benzoesaeure-amid；Tetramethylbenzoesaureamid；2,3,4,5-tetramethylbenzamide
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: PBYBFUYDFWMDHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  五甲基苯 在 五氯化磷 、 硝酸 作用下， 生成 2,3,4,5-tetramethyl-benzoic acid amide
  参考文献：
  名称：

  Studies on the Polymethylbenzenes. XI. The Nitration of Pentamethylbenzene and of Hexamethyl- and Hexaethylbenzene^1,2

  摘要：

  DOI：

  10.1021/ja01310a035

文献信息

• [EN] TANKYRASE INHIBITORS<br/>[FR] INHIBITEURS DE TANKYRASE
  申请人：UNIV BATH

  公开号：WO2014087165A1

  公开（公告）日：2014-06-12

  The present invention relates to a compound of formula I wherein X is C(R6) or N, Y is C or N, and ring A, ring B, R1 and R2 have the meanings defined herein, provided that when ring B is carbocyclic, X is C(R6); or a pharmaceutically acceptable salt or solvate thereof. The compounds are tankyrase-1 and tankyrase-2 inhibitors and are useful in the treatment of a number of conditions, including cancer.

  本发明涉及一种具有式I的化合物，其中X为C(R6)或N，Y为C或N，环A、环B、R1和R2具有本文中定义的含义，前提是当环B为碳环时，X为C(R6)；或其药学上可接受的盐或溶剂。这些化合物是坦克酶-1和坦克酶-2抑制剂，并可用于治疗多种疾病，包括癌症。
• PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
  申请人：Marsilje Thomas H.

  公开号：US20110112096A1

  公开（公告）日：2011-05-12

  The invention provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).

  本发明提供了式(I)的新型嘧啶衍生物及其制药组合物，以及使用这些化合物的方法。例如，本发明的嘧啶衍生物可用于治疗、改善或预防对胰岛素样生长因子（IGF-IR）或无形淋巴瘤激酶（ALK）的抑制有反应的疾病。
• Isolated nucleic acid molecules encoding a bacterial uracil phosphoribosyl-transferase enzyme, cells transformed therewith and uses thereof
  申请人：Merck & Co., Inc.

  公开号：EP1930420A1

  公开（公告）日：2008-06-11

  Disclosed herein are novel polynucleotides encoding a uracil phosphoribosyl transferase, each being derived from Salmonella typhimurium. The disclosed uracil phosphoribosyl transferase protein is useful in sensitizing human cancer cells to treatment with anti-cancer agents such as 5-Fluorouracil.

  本文公开了编码尿嘧啶磷酸核糖转移酶的新型多核苷酸，每种多核苷酸都来自鼠伤寒沙门氏菌。所公开的尿嘧啶磷酸核糖基转移酶蛋白可使人类癌细胞对 5-氟尿嘧啶等抗癌剂的治疗敏感。
• Beta-secretase substrates and uses thereof
  申请人：Merck & Co., Inc.

  公开号：EP1990057A1

  公开（公告）日：2008-11-12

  The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.

  本发明提供的合成β-分泌酶多肽底物可用于各种测定β-分泌酶活性的试验。还公开了识别合成底物的抗体以及抗体在各种检测中的用途。本文公开的肽底物的水解速度大大快于底物序列来源的瑞典突变APP。
• Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein
  申请人：Dr. Rentschler Holding GmbH & Co. KG

  公开号：EP2366714A1

  公开（公告）日：2011-09-21

  The present invention refers to human antibodies which are directed against α-Synuclein (α-Syn) and their use in medicine and diagnosis.

  本发明是指针对α-突触核蛋白（α-Syn）的人类抗体及其在医学和诊断中的应用。