7-(4,6-difluoroindol-1-yl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7-(4,6-difluoroindol-1-yl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine
• 化学式: C₁₈H₁₆F₂N₂O₂S
• 分子量: 362.4
• InChiKey: CHVUYBOCNPVDFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Benzo[d]azepine derivatives as 5-ht6 receptor anatagonists
  申请人：——

  公开号：US20040192671A1

  公开（公告）日：2004-09-30

  The invention relates to novel compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.

  本发明涉及具有药理活性的新化合物，其制备方法，包含它们的组合物以及它们在治疗各种疾病中的应用。
• BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS.
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1392316A1

  公开（公告）日：2004-03-03
• [EN] BENZO[D]AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS.<br/>[FR] DERIVES DE BENZO[D]AZEPINE UTILES COMME ANTAGONISTES DU RECEPTEUR 5-HT6
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2002089811A1

  公开（公告）日：2002-11-14

  The invention relates to novel compounds (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of disorders such like depression, anxiety and Alzheimers disease.