1-Methyl-5-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazino[4,5-c]pyridazine-3-carboxylic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Methyl-5-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazino[4,5-c]pyridazine-3-carboxylic acid ethyl ester
• 英文别名: ethyl 1-methyl-5-oxo-6-phenyl-4H-pyridazino[3,4-d]pyridazine-3-carboxylate
• 化学式: C₁₆H₁₆N₄O₃
• 分子量: 312.328
• InChiKey: UUXVRAQVSVSRKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-氯-5-(1-甲基肼基)-2-苯基-2,3-二氢哒嗪-3-酮 在 锌铜偶 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 36.0h， 生成 1-Methyl-5-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazino[4,5-c]pyridazine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Yamasaki, Tetsuo; Oda, Mitsuo; Okamoto, Yoshinari, Heterocycles, 1996, vol. 43, # 9, p. 1863 - 1872

  摘要：

  DOI：

文献信息

• Interleukin-1 blocker for use in the treatment of age-related macular degeneration
  申请人：THE TEXAS A & M UNIVERSITY SYSTEM

  公开号：EP2508183A1

  公开（公告）日：2012-10-10

  The present invention relates to a composition for use in the treatment of age-related macular degeneration comprising an interleukin-1 blocker.

  本发明涉及一种用于治疗老年性黄斑变性的组合物，其中包含一种白细胞介素-1阻断剂。
• Hydralazine for use in the treatment of age-related macular degeneration
  申请人：THE TEXAS A & M UNIVERSITY SYSTEM

  公开号：EP2508182A1

  公开（公告）日：2012-10-10

  The present invention relates to a composition comprising hydralazine or salt thereof for use in the treatment of age-related macular degeneration.

  本发明涉及一种包含肼屈嗪或其盐的组合物，用于治疗老年性黄斑变性。
• Therapeutic Compositions And Methods
  申请人：Chiou George C.

  公开号：US20120071485A1

  公开（公告）日：2012-03-22

  The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.
• THERAPEUTIC COMPOSITIONS AND METHODS
  申请人：CHIOU GEORGE C.

  公开号：US20120196868A1

  公开（公告）日：2012-08-02

  The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.
• US8088773B2
  申请人：——

  公开号：US8088773B2

  公开（公告）日：2012-01-03