1-Pentyl-4-[(4-phenylmethoxyphenyl)methyl]-1,4-diazepane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Pentyl-4-[(4-phenylmethoxyphenyl)methyl]-1,4-diazepane
• 化学式: C₂₄H₃₄N₂O
• 分子量: 366.5
• InChiKey: XKUMNTAOPJBWRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1140880A1

  公开（公告）日：2001-10-10
• [EN] HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS<br/>[FR] DERIVES HOMOPIPERAZINE EN TANT QU'INHIBITEURS SELECTIFS DE L'EMOPAMILE
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000039110A1

  公开（公告）日：2000-07-06

  Homopiperazines of formula (I), wherein R1 is hydrogen, C¿1-8?alkyl, C2-8alkenyl or C2-8alkynyl substituted or unsubstituted with a variety of groups as defined herein; A is a ring selected from phenyl and naphthyl; R?2¿ at each occurrence is independently selected from a variety of groups as defined herein; m is an integer selected from the range 0 to 5 where at each occurrence R2 is independently selected; together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful in the treatment of neurological disorders.