6-(2-methyl-2H-1,2,4-triazol-3-ylmethyloxy)-7-phenyl-3-(pyrazin-2-yl)-1,2,4-triazolo[4,3-b]pyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(2-methyl-2H-1,2,4-triazol-3-ylmethyloxy)-7-phenyl-3-(pyrazin-2-yl)-1,2,4-triazolo[4,3-b]pyridazine
• 英文别名: 6-[(2-Methyl-1,2,4-triazol-3-yl)methoxy]-7-phenyl-3-pyrazin-2-yl-[1,2,4]triazolo[4,3-b]pyridazine
• 化学式: C₁₉H₁₅N₉O
• 分子量: 385.388
• InChiKey: SOEAAAOQLJICJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1107967A2

  公开（公告）日：2001-06-20
• US6297235B1
  申请人：——

  公开号：US6297235B1

  公开（公告）日：2001-10-02
• US6444666B1
  申请人：——

  公开号：US6444666B1

  公开（公告）日：2002-09-03
• [EN] TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION<br/>[FR] DERIVES DE TRIAZOLOPYRIDAZINE, UTILISE COMME ANXIOLYTIQUES ET AMELIORANTS COGNITIFS
  申请人：MERCK SHARP & DOHME

  公开号：WO2000012505A2

  公开（公告）日：2000-03-09

  A compound of formula (I), or a salt or prodrug thereof wherein: Z represents C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, aryl, C3-7 heterocycloalkyl, heteroaryl, di(C1-6)alkylamino or C6-12 bicycloalkyl, any of which groups may be optionally substituted; R1 represents an optionally substituted five-membered heteroaromatic ring selected from pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyrazole, oxadiazole, thiadiazole, triazole and tetrazole; or R1 represents an optionally substituted six-membered heteroaromatic ring selected from pyridine, pyrazine, pyrimidine and pyridazine; and R2 represents cyano(C¿1-6?)alkyl, hydroxy(C1-6)alkyl, C3-7 cycloalkyl(C1-6)alkyl, propargyl, C3-7 heterocycloalkylcarbonyl(C1-6)alkyl, aryl(C1-6)alkyl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted; its use in treating anxiety and pharmaceutical compositions comprising it; a subclass of compounds which are useful in enhancing cognition, such as Alzheimer's Disease, is also disclosed.