N-{4-[2-(3-aminophenylamino)pyrimidin-4-yl]phenyl}-2-morpholin-4-yl-2-phenyl-acetamide | 663611-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-{4-[2-(3-aminophenylamino)pyrimidin-4-yl]phenyl}-2-morpholin-4-yl-2-phenyl-acetamide
• 英文别名: N-[4-[2-(3-aminoanilino)pyrimidin-4-yl]phenyl]-2-morpholin-4-yl-2-phenylacetamide
• CAS: 663611-47-0
• 化学式: C₂₈H₂₈N₆O₂
• 分子量: 480.569
• InChiKey: BIJLEJFYLRTJGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Protein kinase inhibitors and uses thereof
  申请人：——

  公开号：US20040106615A1

  公开（公告）日：2004-06-03

  Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: 1 or a pharmaceutically acceptable salt thereof, wherein Ring B, Z 1 , Z 2 , U, T, m, n, p, Q, Q′, R 1 , R 2 , R x , R 3 , and R 6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.

  本文描述了以下具有I和V式的蛋白激酶抑制剂化合物，或其药学上可接受的盐：其中环B、Z1、Z2、U、T、m、n、p、Q、Q′、R1、R2、Rx、R3和R6如本文所定义。这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重程度，包括中风、炎症性疾病、自身免疫性疾病，如SLE狼疮和银屑病、增殖性疾病，如癌症，以及与器官移植相关的疾病。
• PROTEIN KINASE INHIBITORS AND USES THEREOF
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP1546117A2

  公开（公告）日：2005-06-29
• US7304071B2
  申请人：——

  公开号：US7304071B2

  公开（公告）日：2007-12-04
• [EN] PROTEIN KINASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA PROTEINE KINASE ET LEURS UTILISATIONS
  申请人：VERTEX PHARMA

  公开号：WO2004016597A2

  公开（公告）日：2004-02-26

  Described herein are compounds that are useful as protein kinase inhibitors having the formulae (I) and (V) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2 U, T, m, n, p, Q, Q', R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.