2-[4-methyl-2-[(6-methyl-1H-benzimidazol-2-yl)amino]-6-oxo-1H-pyrimidin-5-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[4-methyl-2-[(6-methyl-1H-benzimidazol-2-yl)amino]-6-oxo-1H-pyrimidin-5-yl]acetic acid
• 化学式: C₁₅H₁₅N₅O₃
• 分子量: 313.31
• InChiKey: DKXGYNYQXDFZBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  120
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• NEW BENZIMIDAZOLE COMPOUNDS FOR USE AS ACTIVE THERAPEUTIC SUBSTANCES, PROCESS FOR THE PREPARATION OF THESE COMPOUDNS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia AB

  公开号：EP1155014A1

  公开（公告）日：2001-11-21
• US6329383B1
  申请人：——

  公开号：US6329383B1

  公开（公告）日：2001-12-11
• [EN] NEW BENZIMIDAZOLE COMPOUNDS FOR USE AS ACTIVE THERAPEUTIC SUBSTANCES, PROCESS FOR THE PREPARATION OF THESE COMPOUDNS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] NOUVEAUX COMPOSES DE BENZIMIDAZOLE POUVANT ETRE UTILISES COMME PRINCIPES ACTIFS THERAPEUTIQUES, PROCEDE PERMETTANT DE LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA & UPJOHN AB

  公开号：WO2000043387A1

  公开（公告）日：2000-07-27

  The present invention relates to new benzimidazole compounds with general structure (I): in which Y-X is ⊃C = X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or Y-X is ⊃C-X when X is H, alkyl, substituted alkyl, aryl, substituted aryl, OR9 or NHR9 and R2 is a bond to Y; Z = O, S or NR12; R1 is H, alkyl, substituted alkyl, aryl or substituted aryl; R3 is H, alkyl, substituted alkyl, aryl or substituted aryl, OR9 or NHR9; R4, R5, R6, R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination and/or two adjacent R4, R5, R6 or R7 form a carbocyclic or heterocyclic ring; R8, R9, R10, R11, R12 and R13 are H, alkyl, substituted alkylaryl, aryl and/or substituted aryl in any combination. These compounds are useful as a human Growth Hormone (hGH) mimetic, which trigger GH agonist effects in animals and especially as an orally availabel human Growth Hormone (hGH).