4-methylesculetin 6,7-bis(stearate) | 158754-15-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-methylesculetin 6,7-bis(stearate)
• 英文别名: (4-Methyl-7-octadecanoyloxy-2-oxochromen-6-yl) octadecanoate
• CAS: 158754-15-5
• 化学式: C₄₆H₇₆O₆
• 分子量: 725.106
• InChiKey: KBMFQNHPYQUPPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.1
• 重原子数：
  52
• 可旋转键数：
  36
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• CONTROLLED RELEASE ORAL PREPARATIONS OF ESCULETIN AND ITS DERIVATIVES
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP1121931A1

  公开（公告）日：2001-08-08

  The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming polymer base, preferably hydroxypropylmethylcellulose. The preparation may be coated with an enteric polymer base such as hydroxypropylmethylcellulose acetate succinate to thereby enhance solubility in the intestines. When orally administered, the preparation can continuously release esculetin. Thus, the administration frequency and dose can be reduced and a therapeutic effect on arthropathy can be established.

  本发明涉及一种控释埃斯库雷丁口服制剂。本发明的控释鱼藤素口服制剂包括凝胶形成聚合物基质，最好是羟丙基甲基纤维素。该制剂可涂覆羟丙基甲基纤维素醋酸琥珀酸酯等肠道聚合物基质，从而提高在肠道中的溶解度。 口服给药时，制剂可持续释放埃斯库莱汀。因此，可以减少给药次数和剂量，并对关节病产生治疗效果。
• Esculetin derivatives and pharmaceutical composition
  申请人：KUREHA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0614896B1

  公开（公告）日：1998-12-30
• US5455268A
  申请人：——

  公开号：US5455268A

  公开（公告）日：1995-10-03
• US6750249B1
  申请人：——

  公开号：US6750249B1

  公开（公告）日：2004-06-15
• [EN] METHOD FOR INHIBITING FIBROCARTILAGE DEGRADATION<br/>[FR] PROCEDE VISANT A INHIBER LA DEGRADATION DU CARTILAGE FIBREUX
  申请人：UNIV RUSH MEDICAL CENTER

  公开号：WO2005091960A2

  公开（公告）日：2005-10-06

  Described herein is a method for inhibiting cartilage, typically fibrocartilage, degradation using esculetin and chemically related compounds. In some embodiments, the esculetin compound is used to prevent degradation of intervertebral disc tissues.