N-(3-chlorophenyl)-2-[(5-pyridin-4-yl-1H-imidazol-2-yl)sulfanyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-chlorophenyl)-2-[(5-pyridin-4-yl-1H-imidazol-2-yl)sulfanyl]acetamide
• 化学式: C₁₆H₁₃ClN₄OS
• 分子量: 344.8
• InChiKey: YFJHMNUFLFDRFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions and methods for inhibiting TGF-beta
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20040157861A1

  公开（公告）日：2004-08-12

  This invention provides compounds that are inhibitors of the TGF-&bgr; signaling pathway. The compounds are represented by formula I: 1 where A′ is N or CH; Ring B is preferably an triazolyl, imidazolyl, or thiazolyl ring; —X-D- is a linker group; and G is an optionally substituted aryl or heteroaryl ring. The compounds are useful for treating cardiovascular disease.

  该发明提供了一些抑制TGF-&bgr;信号通路的化合物。这些化合物由公式I表示：其中A'是N或CH；环B最好是三唑基、咪唑基或噻唑基环；—X-D-是连接基团；G是可选的取代芳基或杂环基。这些化合物可用于治疗心血管疾病。
• COMPOSITIONS AND METHODS FOR INHIBITING TGF-&bgr;
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：EP1581222A2

  公开（公告）日：2005-10-05
• US7361669B2
  申请人：——

  公开号：US7361669B2

  公开（公告）日：2008-04-22
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING TGF-beta<br/>[FR] COMPOSITIONS ET PROCEDES PERMETTANT D'INHIBER LE TGF- DOLLAR G(B)
  申请人：MILLENNIUM PHARM INC

  公开号：WO2004060362A2

  公开（公告）日：2004-07-22

  This invention provides compounds that are inhibitors of the TGF-β signaling pathway. The compounds are represented by formula (I), where A’ is N or CH; Ring B is preferably a triazolyl, imidazolyl, or thiazolyl ring; -X-D- is a linker group; and G is an optionally substituted aryl or heteroaryl ring. The compounds are useful for treating cardiovascular disease.