2-(3-chloro-4-methyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydropyran-4-ylmethyl)-amide | 666262-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(3-chloro-4-methyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydropyran-4-ylmethyl)-amide
• 英文别名: 2-(3-chloro-4-methylanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
• CAS: 666262-41-5
• 化学式: C₁₉H₂₀ClF₃N₄O₂
• 分子量: 428.842
• InChiKey: VTOGLNXCMXYCJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.1
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Pyrimidine derivatives and their use as CB2 modulators
  申请人：Eatherton John Andrew

  公开号：US20060293354A1

  公开（公告）日：2006-12-28

  The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.

  本发明涉及新型嘧啶衍生物、含有这些化合物的药物组合物以及它们在治疗疾病，特别是由大麻素受体活性的增加或减少直接或间接引起的疼痛方面的用途。
• Pyrimidine Derivatives And Their Use As CB2 Modulators
  申请人：Eatherton Andrew John

  公开号：US20100041654A1

  公开（公告）日：2010-02-18

  This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.

  本发明涉及新的嘧啶衍生物、含有这些化合物的药物组合物以及它们在治疗疾病中的应用，特别是治疗由于大麻素受体活性增加或减少而直接或间接引起的疼痛等疾病。
• US7635701B2
  申请人：——

  公开号：US7635701B2

  公开（公告）日：2009-12-22