Piperazine, 1-acetyl-4-[4-[[4-(4-chlorophenyl)-2-pyrimidinyl]amino]benzoyl]-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Piperazine, 1-acetyl-4-[4-[[4-(4-chlorophenyl)-2-pyrimidinyl]amino]benzoyl]-
• 英文别名: 1-[4-[4-[[4-(4-chlorophenyl)pyrimidin-2-yl]amino]benzoyl]piperazin-1-yl]ethanone
• 化学式: C₂₃H₂₂ClN₅O₂
• 分子量: 435.9
• InChiKey: YCOOGLSVZRCSMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• IKK Inhibitors for the Treatment of Endometriosis
  申请人：Merck Serono S.A.

  公开号：EP2266561A2

  公开（公告）日：2010-12-29

  This invention relates to a method of treating and/or preventing endometriosis comprising administering an TKK inhibitor. The TKK inhibitor can also be administered combined with a hormonal suppressor. The invention further relates to the treatment of endometriosis-related infertility.

  本发明涉及一种治疗和/或预防子宫内膜异位症的方法，包括给药 TKK 抑制剂。TKK 抑制剂还可与激素抑制剂结合使用。本发明还涉及子宫内膜异位症相关不孕症的治疗。
• Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
  申请人：——

  公开号：US20040087642A1

  公开（公告）日：2004-05-06

  The present invention relates to methods for treating, preventing, managing and/or modifying pain, comprising administering an effective amount of a JNK Inhibitor to a patient in need thereof. Specific embodiments encompass the administration of a JNK Inhibitor, alone or in combination with a second active agent and/or surgery or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

  本发明涉及治疗、预防、控制和/或改变疼痛的方法，包括向有需要的患者施用有效量的JNK抑制剂。具体的实施方案包括单独或与第二种活性剂和/或手术或物理疗法联合使用 JNK 抑制剂。本发明还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。
• JNK INHIBITORS FOR THE TREATMENT OF CNS INJURY
  申请人：CELGENE CORPORATION

  公开号：EP1827422A2

  公开（公告）日：2007-09-05
• IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS
  申请人：Laboratoires Serono SA

  公开号：EP1931322A1

  公开（公告）日：2008-06-18
• AN ORAL PHARMACEUTICAL COMPOSITION OF AN ANILINOPYRIMIDINE, ITS PREPARATION AND USE THEREOF
  申请人：Ares Trading S.A.

  公开号：EP2037897A2

  公开（公告）日：2009-03-25