Benzo[12,1]tetrapheno[4,5-bc]oxete-4,5-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: Benzo[12,1]tetrapheno[4,5-bc]oxete-4,5-diol
• 英文别名: 2-oxahexacyclo[15.3.1.03,20.06,19.09,18.010,15]henicosa-1(21),3(20),4,6(19),7,9(18),10,12,14,16-decaene-16,21-diol
• 化学式: C₂₀H₁₀O₃
• 分子量: 298.3
• InChiKey: MROJFLLSHCPDHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Compositions and Methods for Cellular Imaging and Therapy
  申请人：Yang J. David

  公开号：US20070248537A1

  公开（公告）日：2007-10-25

  The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N 4 compounds and derivatives.

  本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N4化合物及其衍生物的成分、试剂盒和成像和治疗方法。
• COMPOSITIONS AND METHODS INVOLVING GENE THERAPY AND PROTEASOME MODULATION
  申请人：Ramesh Rajagopal

  公开号：US20090004145A1

  公开（公告）日：2009-01-01

  The present invention concerns the methods and compositions involving a therapeutic polypeptide, such as a tumor suppressor or a nucleic acid encoding such in combination with a proteasome inhibitor, for the treatment of cancer. In certain examples, a treatment for ovarian cancer is provided.

  本发明涉及使用治疗性多肽（例如肿瘤抑制剂）或编码其的核酸与蛋白酶体抑制剂结合的方法和组合物，用于治疗癌症。在某些例子中，提供了一种治疗卵巢癌的方法。
• DEVICE FOR ASSAYING POLYMORPHISMS OF GENE XPD/ERCC2 FOR THE CORRECT ADMINISTRATION OF CHEMOTHERAPY FOR LUNG CANCER
  申请人：Fundacion para la Investigacion Clinica y Molecular del Cancer de Pulmon

  公开号：EP1584691A1

  公开（公告）日：2005-10-12

  The invention is encompassed in the technical sector of lung cancer treatment with antitumor drugs, and it specifically develops a diagnostic device which allows treating each patient with the most effective drug according to the polymorphism they show for the XPD gene. The assay device of the invention is based on the polymorphic variants of the XPD gene at exon 23 (A-C, Lys 751 Gln) and at exon 10 (G-A, Asp312Asn) and on the development of specific primers which allow detecting said polymorphisms by PCR or by means of automatic DNA sequencing.

  本发明属于用抗肿瘤药物治疗肺癌的技术领域，它特别开发了一种诊断装置，可根据每位患者的 XPD 基因多态性，用最有效的药物对其进行治疗。本发明的检测装置基于 XPD 基因第 23 号外显子（A-C，Lys 751 Gln）和第 10 号外显子（G-A，Asp312Asn）的多态性变体，并基于特定引物的开发，这些引物可通过 PCR 或自动 DNA 测序检测上述多态性。
• Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
  申请人：EUKARION, INC.

  公开号：EP1642583A2

  公开（公告）日：2006-04-05

  The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.

  本发明提供了适于药物治疗的抗氧化沙林金属复合物，用于治疗或预防与超氧化物等自由基产生的细胞或组织损伤有关的疾病。
• Assay device of XPD/ERCC2 gene polymorphisms for the correct administration of chemotherapy in lung cancer
  申请人：Pangaea Biotech, S.A.

  公开号：EP1905847A2

  公开（公告）日：2008-04-02

  The invention is encompassed in the technical sector of lung cancer treatment with antitumor drugs, and it specifically develops a diagnostic device which allows treating each patient with the most effective drug according to the polymorphism they show for the XPD gene. The assay device of the invention is based on the polymorphic variants of the XPD gene at exon 23 (A-C, Lys 751 Gln) and at exon 10 (G-A, Asp312Asn) and on the development of specific primers which allow detecting said polymorphisms by PCR or by means of automatic DNA sequencing.

  本发明属于用抗肿瘤药物治疗肺癌的技术领域，它特别开发了一种诊断装置，可根据每位患者的 XPD 基因多态性，用最有效的药物对其进行治疗。本发明的检测装置基于 XPD 基因第 23 号外显子（A-C，Lys 751 Gln）和第 10 号外显子（G-A，Asp312Asn）的多态性变体，并基于特定引物的开发，这些引物可通过 PCR 或自动 DNA 测序检测上述多态性。