6-(1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepin-2-yl)hexanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 6-(1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepin-2-yl)hexanoic acid
• 英文别名: 6-(1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepin-2-yl)caproic acid；6-(2,5-Diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaen-5-yl)hexanoic acid
• 化学式: C₂₃H₂₈N₂O₂
• 分子量: 364.488
• InChiKey: VUKQGADZCYFWQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0421823A2

  公开（公告）日：1991-04-10

  Compounds of formula (I): [in which; Q is nitrogen or =CH-; R1 and R2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R3 is various specific substituted alkyl groups] and pharmaceutically acceptable salts thereof have valuable anti-allergic and anti-asthmatic activities. They may be prepared by reacting a corresponding compound where R3 is replaced by a hydrogen atom with a compound to introduce the group R3.

  式(I)化合物： [其中，Q 为氮或 =CH-；R1 和 R2 为氢、烷基、烷氧基、羟基、三氟甲基或卤素；R3 为各种特定的取代烷基]及其药学上可接受的盐类具有重要的抗过敏和抗哮喘活性。它们可以通过将 R3 被氢原子取代的相应化合物与引入基团 R3 的化合物反应来制备。
• A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same
  申请人：HOKURIKU PHARMACEUTICAL CO., LTD.

  公开号：EP0447857A1

  公开（公告）日：1991-09-25

  Novel polycyclic compounds represented by the following formula: A - (CH₂)n - COOR¹, wherein R¹ represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represented by the following formula: wherein X represents a hydrogen atom or a halogen atom; and Y represents a methylene group, an oxygen atom, or a sulfur atom, or A is a group represented by the following formula: and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same, an antiallergic agent and an agent for bronchial asthma comprising the same, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

  由下式表示的新型多环化合物：A - (CH₂)n - COOR¹，其中 R¹ 代表氢原子或低级烷基；n 代表 0 至 5 的整数；以及 A 是下式所代表的基团： 其中 X 代表氢原子或卤原子；Y 代表亚甲基、氧原子或硫原子，或者 A 是下式所代表的基团： 及其药理上可接受的盐类。还公开了制备上述物质的方法、包含上述物质的药物组合物、包含上述物质的抗过敏制剂和支气管哮喘制剂，以及包含给药步骤的治疗过敏性疾病或支气管哮喘的方法。
• Methods of treating a sleep disorder
  申请人：Edgar M. Dale

  公开号：US20060063754A1

  公开（公告）日：2006-03-23

  The invention relates to methods of modulating sleep.

  本发明涉及调节睡眠的方法。
• US5344828A
  申请人：——

  公开号：US5344828A

  公开（公告）日：1994-09-06
• US5362725A
  申请人：——

  公开号：US5362725A

  公开（公告）日：1994-11-08