thalrugosaminine | 22226-73-9

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: thalrugosaminine
• 英文别名: Thalrugosaminin (S,S)；5,6,7,6',12'-pentamethoxy-2,2'-dimethyl-(1'αH)-oxyacanthane；(-)-Thalrugosaminine；(1S,14S)-6,19,20,21,25-pentamethoxy-15,30-dimethyl-8,23-dioxa-15,30-diazaheptacyclo[22.6.2.29,12.13,7.114,18.027,31.022,33]hexatriaconta-3(36),4,6,9(35),10,12(34),18(33),19,21,24,26,31-dodecaene
• CAS: 22226-73-9
• 化学式: C₃₉H₄₄N₂O₇
• 分子量: 652.788
• InChiKey: HKAAPKXOAPZXLY-KYJUHHDHSA-N

物化性质

• 熔点：
  163-166℃
• 沸点：
  732.8±60.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3 (20 ºC 760 Torr)
• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  48
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  9

制备方法与用途

生物活性

thalrugosaminine 是从负藻 (Thalictrum minus) 的根中分离出的苄基异喹啉生物碱。研究表明，thalrugosaminine 具有良好的抗菌活性，其 MIC 值为 64-128 µg/ml。

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 thaligosinine 以 甲醇 、 乙醚 为溶剂， 反应 72.0h， 生成 thalrugosaminine
  参考文献：
  名称：

  Alkaloids of Thalictrum. 25. Six new bisbenzylisoquinoline alkaloids from Thalictrum rugosum

  摘要：

  DOI：

  10.1021/jo00398a012

文献信息

• PRODUCTION METHOD FOR T CELLS OR NK CELLS, MEDIUM FOR CULTURING T CELLS OR NK CELLS, METHOD FOR CULTURING T CELLS OR NK CELLS, METHOD FOR MAINTAINING UNDIFFERENTIATED STATE OF UNDIFFERENTIATED T CELLS, AND GROWTH-ACCELERATING AGENT FOR T CELLS OR NK CELLS
  申请人：KIRIN HOLDINGS KABUSHIKI KAISHA

  公开号：US20220017867A1

  公开（公告）日：2022-01-20

  An object of the present invention is to provide a method for producing T cells or NK cells, a culture medium for culturing T cells or NK cells, a method for culturing T cells or NK cells, a method for maintaining the undifferentiated state of undifferentiated T cells, and a growth promoter for T cells or NK cells, which are capable of efficiently proliferating T cells or NK cells and maintaining the state of the cells (for example, undifferentiated property). The present invention relates to a method for producing T cells or NK cells including culturing T cells or NK cells in a culture medium containing a bisbenzylisoquinoline alkaloid represented by formula (X-1) or formula (X-2) or a compound resulting from cleavage of one ether bond thereof or a pharmaceutically acceptable salt thereof, and the like.
• Alkaloids of Thalictrum. 25. Six new bisbenzylisoquinoline alkaloids from Thalictrum rugosum
  作者：Wu-Nan Wu、Jack L. Beal、Edward H. Fairchild、Raymond W. Doskotch

  DOI：10.1021/jo00398a012

  日期：1978.2