N,N-di(nitrobenzene-4-sulfonyl)(thiophen-2-yl)amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-di(nitrobenzene-4-sulfonyl)(thiophen-2-yl)amine
• 英文别名: 4-nitro-N-(4-nitrophenyl)sulfonyl-N-thiophen-2-ylbenzenesulfonamide
• 化学式: C₁₆H₁₁N₃O₈S₃
• 分子量: 469.477
• InChiKey: DONVFJYGFTXNLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  208
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  噻吩 、 4-硝基苯磺酰胺 在 [Ru(II)(meso-tetrakis(tolyl)porphyrin)(CO)] 碘苯二乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以60%的产率得到N,N-di(nitrobenzene-4-sulfonyl)(thiophen-2-yl)amine
  参考文献：
  名称：

  Ruthenium(II) Porphyrin-Catalyzed Amidation of Aromatic Heterocycles

  摘要：

  Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles with iminoiodanes under mild conditions (CH2Cl2, 4 Angstrom molecular sieves, ultrasound, 40 degreesC) was achieved in moderate to good yields (up to 84%) and conversions (up to 99%). Only the N,N-ditosylamidated product was obtained for reactions involving heteroarenes, where X = O, S, or NTs. N-Alkyl- and N-aryl-substituted pyrroles, on the other hand, were shown to give the 3,4-diaminated adduct.

  DOI：

  10.1021/ol049232j

文献信息

• Ruthenium(II) Porphyrin-Catalyzed Amidation of Aromatic Heterocycles
  作者：Ling He、Philip Wai Hong Chan、Wai-Man Tsui、Wing-Yiu Yu、Chi-Ming Che

  DOI：10.1021/ol049232j

  日期：2004.7.1

  Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles with iminoiodanes under mild conditions (CH2Cl2, 4 Angstrom molecular sieves, ultrasound, 40 degreesC) was achieved in moderate to good yields (up to 84%) and conversions (up to 99%). Only the N,N-ditosylamidated product was obtained for reactions involving heteroarenes, where X = O, S, or NTs. N-Alkyl- and N-aryl-substituted pyrroles, on the other hand, were shown to give the 3,4-diaminated adduct.