2,2'-tetrasulfanediyldianiline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-tetrasulfanediyldianiline
• 英文别名: 2-[(2-Aminophenyl)tetrasulfanyl]aniline
• 化学式: C₁₂H₁₂N₂S₄
• 分子量: 312.505
• InChiKey: ZVHFOOSFGGEXBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基苯硫醇 在 硫化氢 、 三乙胺 作用下， 反应 2.0h， 以42%的产率得到2,2'-trisulfanediyldianiline
  参考文献：
  名称：

  Do, Quang Tho; Elothmani, Driss; Simonet, Jacques, Bulletin de la Societe Chimique de France, 1996, vol. 133, # 3, p. 273 - 281

  摘要：

  DOI：

文献信息

• Highly efficient synthesis of 2-mercaptobenzothiazole derivatives in water: metal sulfide–disulfide dynamic interchange reaction
  作者：Chunqing Lou、Ning Zhu、Ronghua Fan、Hailong Hong、Limin Han、Jianbin Zhang、Quanling Suo

  DOI：10.1039/c6gc03053j

  日期：——

  A convenient and efficient method for the synthesis of 2-mercaptobenzothiazoles from disulfide and CS2 mediated by metal sulfide in water is described. This synthetic methodology could be used to prepare...

  描述了一种方便有效的方法，该方法由金属硫化物在水中从二硫化物和CS2合成2-巯基苯并噻唑。这种综合方法可用于制备...
• Accelerated reduction and solubilization of elemental sulfur by 1,2-aminothiols
  作者：Jonathan T. Stoffel、Kimberly T. Riordan、Emily Y. Tsui

  DOI：10.1039/d1cc05242j

  日期：——

  Nucleophilic 1,2-aminothiol compounds readily reduce typically-insoluble elemental sulfur to polysulfides in both water and nonpolar organic solvents. The resulting anionic polysulfide species are stabilized through hydrogen-bonding interactions with the proximal amine moieties. These interactions can facilitate sulfur transfer to alkenes.

  在水和非极性有机溶剂中，亲核 1,2-氨基硫醇化合物很容易将通常不溶的元素硫还原为多硫化物。所得阴离子多硫化物物质通过与近端胺部分的氢键相互作用而稳定。这些相互作用可以促进硫转移到烯烃。
• COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HYPOXIC OR ISCHEMIC INJURY
  申请人：Wintner Edward A.

  公开号：US20100130555A1

  公开（公告）日：2010-05-27

  A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R 1 —(S) n —R 2 (I) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R 1 , R 2 , and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• US8202997B2
  申请人：——

  公开号：US8202997B2

  公开（公告）日：2012-06-19
• [EN] COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HYPOXIC OR ISCHEMIC INJURY<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR TRAITER OU PRÉVENIR UNE LÉSION HYPOXIQUE OU ISCHÉMIQUE
  申请人：IKARIA INC

  公开号：WO2010045582A2

  公开（公告）日：2010-04-22

  A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R1_(S)n-R2 or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.