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N-vinyl-2-phenylacetamide

中文名称
——
中文别名
——
英文名称
N-vinyl-2-phenylacetamide
英文别名
N-vinylphenylacetamide;N-ethenyl-2-phenylacetamide
N-vinyl-2-phenylacetamide化学式
CAS
——
化学式
C10H11NO
mdl
——
分子量
161.203
InChiKey
IQVLNQNLISXIOS-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.6
  • 重原子数:
    12
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.1
  • 拓扑面积:
    29.1
  • 氢给体数:
    1
  • 氢受体数:
    1

反应信息

点击查看最新优质反应信息

文献信息

  • Asymmetric Coupling of Carbon‐Centered Radicals Adjacent to Nitrogen: Copper‐Catalyzed Cyanation and Etherification of Enamides
    作者:Guoyu Zhang、Song Zhou、Liang Fu、Pinhong Chen、Yibiao Li、Jianping Zou、Guosheng Liu
    DOI:10.1002/anie.202008338
    日期:2020.11.9
    The first copper‐catalyzed asymmetric cyanation and etherification reactions of enamides have been established, where a carbon‐centered radical adjacent to a nitrogen atom (CRAN) is enantioselectively trapped by a chiral copper(II) species. Moreover, the asymmetric cyanation of vinyl esters was disclosed as well. These reactions feature very mild reaction conditions and high functional group tolerance
    已经建立了第一个铜催化的酰胺类不对称氰化和醚化反应,其中与氮原子(CRAN)相邻的碳中心自由基被手性铜(II)物种对映选择性地捕获。此外,还公开了乙烯基酯的不对称氰化。这些反应具有非常温和的反应条件和较高的官能团耐受性,并提供了一系列手性的α-氰基酰胺,α-氰基酯和α-半胱氨酸,收率高,对映选择性优异。手性α-氰基酰胺很容易转化为对映体富集的1,2-二胺和氨基酸。
  • <i>N</i>-Nitrosotolazoline: Decomposition Studies of a Typical <i>N</i>-Nitrosoimidazoline
    作者:Richard N. Loeppky、Jianzheng Shi
    DOI:10.1021/tx700318k
    日期:2008.2.1
    protonation of the imino nitrogen atom followed by slow general base-catalyzed addition of H2O to the 2-carbon of the imidazoline ring to give a tetrahedral intermediate, which is also a alpha-hydroxynitrosamine. Rapid decomposition of this species gives rise to the diazonium from which the products are derived by nucleophilic attack, elimination, and rearrangement. The proposed mechanism is supported by
    N-亚硝基噻唑啉(N-亚硝基-2-苄基咪唑啉)是N-亚硝基咪唑啉的典型N-亚硝化药物,可与酸,亚硝酸或N-乙酰基半胱氨酸水溶液反应,产生高度亲电的重氮离子,能够将细胞亲核试剂烷基化。已在无机酸和缓冲液中确定了N-亚硝基偶氮唑啉酸性水解的动力学和机理。提出了在酸性缓冲液中分解的机理,涉及亚氨基氮原子的快速可逆质子化,然后将缓慢的一般碱催化的H2O缓慢加至咪唑啉环的2-碳上,得到四面体中间体,该中间体也是α -羟基亚硝胺。该物质的快速分解产生了重氮鎓,通过亲核攻击,消除,和重新安排。通用酸催化,氘溶剂动力学同位素效应可忽略不计(kH / kD = 1.15)和δS = -34 eu的观察结果支持了所提出的机理。在30摄氏度的磷酸盐缓冲液中,N-亚硝基偶氮唑啉的半衰期在pH值为3.5的5分钟到pH值为6的4小时。水解分解的主要反应产物是N-(2-羟乙基)苯基乙酰胺。该产物和其他产物与反应性重氮离
  • Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
    申请人:McDaniel C. Steven
    公开号:US20100210745A1
    公开(公告)日:2010-08-19
    Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.
    本文公开了一些聚合材料,如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂;一种表面处理,如纺织品涂层或蜡;一种填料,用于这样的聚合材料或表面处理,其中包括一种酶,如酯酶(例如,脂肪水解酶,硫酸酯水解酶,有机磷化合物降解酶),降解细胞壁和/或细胞膜成分的酶(例如,溶菌酶,裂解转糖基酶),生物杀菌或生物静态肽,以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能,如使用寿命、柔韧性或刚度的方法。
  • Polymeric Coatings Incorporating Bioactive Enzymes for Catalytic Function
    申请人:McDaniel C. Steven
    公开号:US20120097194A1
    公开(公告)日:2012-04-26
    Disclosed herein are materials including a polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a coating, a textile finish or a wax; a filler for such a polymeric material or a surface treatment, which includes an enzyme such as an esterase (e.g., a lipolytic enzyme, an organophosphorus compound degradation enzyme), wherein the enzyme decontaminates a chemical from the surface of the material. Also disclosed herein are methods of cleaning a surface of a material that comprises an enzyme.
    本文公开了一种材料,包括聚合物材料,例如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂;表面处理,例如涂层、纺织品处理或蜡;用于上述聚合物材料或表面处理的填料,其中包括酶,例如酯酶(例如脂肪水解酶、有机磷化合物降解酶),其中酶可从材料表面去除化学物质。本文还公开了一种清洁含有酶的材料表面的方法。
  • Polymeric Coatings Incorporating Bioactive Enzymes for Cleaning a Surface
    申请人:Wales Melinda
    公开号:US20110240064A1
    公开(公告)日:2011-10-06
    Disclosed herein are a materials such as a coating, such as an architectural coating or a CARC coating, comprising a lipolytic enzyme or organophosphorous compound degrading enzyme. Also disclosed herein are methods of decontaminating a surface comprising such a material from a chemical substrate of an enzyme such as a lipid or an organophosphorus compound.
    本文公开了一种材料,例如涂层,如建筑涂层或CARC涂层,包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种从酶的化学底物,例如脂质或有机磷化合物,中去除此类材料表面的污染物的方法。
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