1-benzyl-4-(pyrrolidin-1-yl)pyridinium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-benzyl-4-(pyrrolidin-1-yl)pyridinium chloride
• 英文别名: 1-Benzyl-4-pyrrolidin-1-ylpyridin-1-ium;chloride
• 化学式: C₁₆H₁₉N₂*Cl
• 分子量: 274.793
• InChiKey: NBFRIAMFZXVNBS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.37
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-4-(pyrrolidin-1-yl)pyridinium chloride 、 cucurbituril 以 水 为溶剂， 生成
  参考文献：
  名称：

  Supramolecular assemblies controlled by cucurbit[n]uril size (n = 6, 7, 8 and 10)

  摘要：

  Q[n]的不同腔体大小决定了苄基取代的4-吡咯啉吡啶盐与每个Q[n]之间的结合相互作用。报道了客体的单晶X射线衍射以及两个宿主-客体复合物。

  DOI：

  10.1039/d0nj00087f
• 作为产物：
  描述：

  氯化苄 、 4-吡咯烷基吡啶 以 乙腈 为溶剂， 反应 12.0h， 以85%的产率得到1-benzyl-4-(pyrrolidin-1-yl)pyridinium chloride
  参考文献：
  名称：

  Supramolecular assemblies controlled by cucurbit[n]uril size (n = 6, 7, 8 and 10)

  摘要：

  Q[n]的不同腔体大小决定了苄基取代的4-吡咯啉吡啶盐与每个Q[n]之间的结合相互作用。报道了客体的单晶X射线衍射以及两个宿主-客体复合物。

  DOI：

  10.1039/d0nj00087f

文献信息

• POLYFLUORO-1-ALKENE AND METHOD FOR PRODUCING THE SAME
  申请人：Sato Katsuyuki

  公开号：US20110077435A1

  公开（公告）日：2011-03-31

  A polyfluoro-1-alkene represented by the general formula: CF 3 (CF 2 ) n CH 2 (CF 2 ) m CH═CH 2 [I], wherein n is an integer of 0 to 5, and m is an integer of 1 to 7, is produced by reacting a polyfluoroalkyl iodide represented by the general formula: CF 3 (CF 2 ) n CH 2 (CF 2 ) m (CH 2 CH 2 )I [II], wherein n is an integer of 0 to 5, and m is an integer of 1 to 7, with an inorganic basic compound in the presence of a phase transfer catalyst. Alternatively, the polyfluoro-1-alkene is produced by reacting the polyfluoroalkyl iodide [II] with a nitrogen-containing organic basic compound, and is obtained product [I] as one fraction thereof. By the copolymerization of the polyfluoro-1-alkene with other fluorinated olefin monomers, a fluorine-containing copolymer having excellent light transmittance in the visible light range is formed.

  通式表示的多氟-1-烯烃：CF3(CF2)nCH2(CF2)mCH═CH2[I]，其中n为0至5的整数，m为1至7的整数，通过将通式表示的多氟烷基碘化物：CF3(CF2)nCH2(CF2)m(CH2CH2)I [II]，其中n为0至5的整数，m为1至7的整数，与无机碱性化合物在相转移催化剂的存在下反应而制得。另外，通过将多氟烷基碘化物[II]与含氮有机碱性化合物反应，得到产物[I]的一部分。通过将多氟-1-烯烃与其他氟代烯烃单体共聚合，形成具有在可见光范围内优异透光性的含氟共聚物。
• HETEROARYL COMPOUNDS COMPRISING NITROGEN AND USE THEREOF
  申请人：ImmunoMet Therapeutics, Inc

  公开号：US20170305861A1

  公开（公告）日：2017-10-26

  The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compounds according to the present invention exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer with a reduced dose compared to that of existing drugs. Accordingly, the compounds can be effectively used for treating various types of cancer, such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, pancreatic cancer, renal cancer, prostate cancer, bladder cancer, and liver cancer, and for inhibiting proliferation of cancer cells and metastasis of cancer.

  本发明涉及含氮的杂环化合物及其使用，更具体地涉及对抑制癌细胞增殖、转移和复发具有显著作用的化合物、其制备方法以及包含其作为活性成分的药物组合物。与现有药物相比，本发明的化合物在减少剂量的情况下具有显著的抑制癌细胞增殖、转移和复发的作用。因此，这些化合物可以有效地用于治疗各种类型的癌症，如子宫癌、乳腺癌、胃癌、脑癌、直肠癌、结直肠癌、肺癌、皮肤癌、血液癌、胰腺癌、肾癌、前列腺癌、膀胱癌和肝癌，并用于抑制癌细胞的增殖和癌症的转移。
• Novel acrylic copolymer elastomer, its blend rubber and blend rubber composition
  申请人：NIPPON MEKTRON, LTD.

  公开号：EP0761702A2

  公开（公告）日：1997-03-12

  A novel acrylic copolymer elastomer comprising [] an alkyl acrylate; [] (a) CH2=CRCOOR2OCOR1, (b) CH2=CRCO[O(CH2) pCO]qOR1 or (c) CH2=CRCOOR2O[CO(CH2)pO]qCOR1; and [] (1) CH2= CRCOO(CH2)nPhOR', (2) CH2=CRCOO(CH2)nOCO(CH2)mPhOR', (3) CH2= CHOCO(CH2)mPhOR', (4) CH2=CHOCO(CH2)nOCO(CH2)mPhOR', (5) CH2= CHO(CH2)nOCO(CH2)mPhOR' or (6) CH2=CHPh(CH2)nOCO(CH2)mPhOR' where R is a hydrogen atom or a methyl group, R1 is an alkyl group, R2 is an alkylene group, R' is a hydrogen atom, an acyl group or a trialkylsilyl group and Ph is a phenylene group, provides a blend rubber having an improved cold resistance and an intermediate heat resistance between the heat resistance of acrylic copolymer elastomer and that of fluorine-containing elastomer, when blended with the fluorine-containing elastomer.

  一种新型丙烯酸共聚弹性体，包含[]丙烯酸烷基酯；[](a)CH2=CRCOOR2OCOR1，(b)CH2=CRCO[O(CH2)pCO]qOR1 或(c)CH2=CRCOOR2O[CO(CH2)pO]qCOR1；和 [] (1) CH2= CRCOO(CH2)nPhOR', (2) CH2=CRCOO(CH2)nOCO(CH2)mPhOR', (3) CH2= CHOCO(CH2)mPhOR', (4) CH2=CHOCO(CH2)nOCO(CH2)mPhOR'、(5) CH2= CHO(CH2)nOCO(CH2)mPhOR' 或 (6) CH2=CHPh(CH2)nOCO(CH2)mPhOR' 其中 R 是氢原子或甲基，R1 是烷基，R2 是亚烷基，R' 是氢原子、R1 是烷基，R2 是亚烷基，R'是氢原子、酰基或三烷基硅基，Ph 是亚苯基，因此，当与含氟弹性体混合时，混合橡胶的耐寒性得到改善，耐热性介于丙烯酸共聚物弹性体的耐热性和含氟弹性体的耐热性之间。
• NOVEL FLUORINE-CONTAINING POLYMER
  申请人：Asahi Glass Company, Limited

  公开号：EP2065409A1

  公开（公告）日：2009-06-03

  The present invention provides a fluorinated polymer excellent in the crosslinking reactivity, crosslinked rubber physical properties and chemical resistance, and its crosslinked rubber. A fluorinated polymer comprising repeating units (a) based on at least one monomer selected from the group consisting of ethylenic unsaturated compounds each having a hydroxyphenyl group, repeating units (b) based on at least one fluoromonomer selected from the group consisting of tetrafluoroethylene, hexafluoropropylene, vinylidene fluoride, 3,3,3-trifluoropropene, 1,3,3,3-tetrafluoropropene, 1,1,2-trifluoroethylene, vinyl fluoride, 1,2-difluoroethylene and CF2=CF-O-Rf (wherein Rf is a C1-8 saturated perfluoroalkyl group or a perfluoro(alkoxyalkyl) group) and, if necessary, repeating units (c) based on at least one hydrocarbon monomer selected from the group consisting of ethylene, propylene and CH2=CH-O-R1.

  本发明提供了一种在交联反应性、交联橡胶物理性能和耐化学性方面性能优异的含氟聚合物及其交联橡胶。 1,3,3,3-四氟丙烯、1,1,2-三氟乙烯、氟化乙烯、1,2-二氟乙烯和 CF2=CF-O-Rf（其中 Rf 为 C1-8 饱和全氟烷基或全氟（烷氧基烷基）基团）组成的组中的至少一种氟单体为基础的重复单元（c），以及必要时以选自乙烯、丙烯和 CH2=CH-O-R1 组成的组中的至少一种烃单体为基础的重复单元（d）。
• Fluororubber composition
  申请人：NOK CORPORATION

  公开号：EP2740763A1

  公开（公告）日：2014-06-11

  Provided is a fluororubber composition which does not deteriorate workability during roll kneading, does not cause foaming during crosslinking and molding, and is capable of giving a crosslinked molded article which exhibits desired hardness and sealing property without using a reinforcing inorganic filler such as carbon black and silica. The fluororubber composition includes, relative to 100 parts by weight of a vinylidene fluoride-copolymerized, fluorine-containing elastomer copolymer having a glass transition temperature and a melting point, no reinforcing inorganic filler 5 to 100 parts by weight of a PTFE filler, 0.5 to 10 parts by weight of a polyol crosslinking agent, 1 to 15 parts by weight of magnesium oxide, and 0.1 to 2 parts by weight of hydrotalcite. Preferably, 0.1 to 10 parts by weight of a quaternary onium salt crosslinking accelerator is further included.

  本发明提供了一种氟橡胶组合物，该组合物在辊揉过程中不会降低加工性，在交联和成型过程中不会引起发泡，并且能够在不使用无机增强填料（如碳黑和二氧化硅）的情况下获得具有所需硬度和密封性的交联成型品。氟橡胶组合物包括：相对于 100 份（重量）具有玻璃化温度和熔点的偏氟乙烯-共聚含氟弹性体共聚物，不含增强无机填料的 5 至 100 份（重量）聚四氟乙烯填料，0.5 至 10 份（重量）多元醇交联剂，1 至 15 份（重量）氧化镁，以及 0.1 至 2 份（重量）氢铝土。最好再加入 0.1 至 10 份（重量）的季铵盐交联促进剂。