N-cyclohexyl-2-(4-hydroxybutyl)-3-oxoisoindoline-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-cyclohexyl-2-(4-hydroxybutyl)-3-oxoisoindoline-1-carboxamide
• 英文别名: N-cyclohexyl-2-(4-hydroxybutyl)-3-oxo-1H-isoindole-1-carboxamide
• 化学式: C₁₉H₂₆N₂O₃
• 分子量: 330.427
• InChiKey: VCQHQMGQDVBEGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰环已烷 、 4-氨基-1-丁醇 、 邻羧基苯甲醛 以 甲醇 为溶剂， 以98%的产率得到N-cyclohexyl-2-(4-hydroxybutyl)-3-oxoisoindoline-1-carboxamide
  参考文献：
  名称：

  A polymer-Supported [1,3,2]Oxazaphospholidine for the conversion of isothiocyanates to isocyanides and Their subsequent use in an ugi reaction

  摘要：

  The design and synthesis of a new polymer supported reagent for the clean conversion of isothiocyanates to isocyanides under microwave conditions was accomplished. The structurally diverse isocyanides generated were used in an Ugi 3CC, allowing the rapid generation of 2-isoindolinone-7-carboxamide analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00269-x

文献信息

• NEW COMPOUNDS I/418
  申请人：Bjore Annika

  公开号：US20080015237A1

  公开（公告）日：2008-01-17

  There is provided compounds of formula I, wherein R 1 to R 7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了式I的化合物， 其中R1至R7在描述中给出了它们的含义，这些化合物在预防和治疗心律失常方面非常有用，特别是房性和室性心律失常。
• ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS
  申请人：AstraZeneca AB

  公开号：EP2049484A1

  公开（公告）日：2009-04-22
• Isoindoline Derivatives For The Treatment Of Arrhythmias
  申请人：Bjore Annika

  公开号：US20100298392A1

  公开（公告）日：2010-11-25

  There is provided compounds of formula I, wherein R 1 to R 7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
• [EN] ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS<br/>[FR] DÉRIVÉS D'ISOINDOLINE DANS LE TRAITEMENT DES ARYTHMIES
  申请人：ASTRAZENECA AB

  公开号：WO2008008022A1

  公开（公告）日：2008-01-17

  [EN] There is provided compounds of formula I, wherein R¹ to R⁷ have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
  [FR] La présente invention concerne des composés de formule I, où R¹ à R⁷ ont les valeurs données dans la description, qui peuvent être employés dans le traitement prophylactique et thérapeutique des arythmies, en particulier des arythmies auriculaires et ventriculaires.
• A polymer-Supported [1,3,2]Oxazaphospholidine for the conversion of isothiocyanates to isocyanides and Their subsequent use in an ugi reaction
  作者：Steven V. Ley、Stephen J. Taylor

  DOI：10.1016/s0960-894x(02)00269-x

  日期：2002.7

  The design and synthesis of a new polymer supported reagent for the clean conversion of isothiocyanates to isocyanides under microwave conditions was accomplished. The structurally diverse isocyanides generated were used in an Ugi 3CC, allowing the rapid generation of 2-isoindolinone-7-carboxamide analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.