2-amino-3,4,5,6-tetrahydropyridine N-oxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-3,4,5,6-tetrahydropyridine N-oxide
• 化学式: C₅H₁₀N₂O
• 分子量: 114.147
• InChiKey: UDXQHSISQMTQKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.04
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.09
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  5-溴戊腈 在 氯化铵 、 锌 、 sodium nitrite 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 20.0h， 生成 2-amino-3,4,5,6-tetrahydropyridine N-oxide
  参考文献：
  名称：

  Cortamidine Oxide, a Novel Disulfide Metabolite from the New Zealand Basidiomycete (Mushroom) Cortinarius Species

  摘要：

  Three disulfide metabolites were isolated from the fruiting bodies of the basidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zealand. The structures of these compounds were determined as the unsymmetrical disulfide cortamidine oxide (1), 2,2 ' -dithiobis(pyridine N-oxide) (2), and the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobial activity and cytotoxicity. 2,2 ' -Dithiobis(pyridine N-oxide) (2) and the symmetrical disulfide 3 are assumed to be artifacts of the isolation procedure.

  DOI：

  10.1021/np000408+

文献信息

• Cortamidine Oxide, a Novel Disulfide Metabolite from the New Zealand Basidiomycete (Mushroom) <i>Cortinarius</i> Species
  作者：Gillian M. Nicholas、John W. Blunt、Murray H. G. Munro

  DOI：10.1021/np000408+

  日期：2001.3.1

  Three disulfide metabolites were isolated from the fruiting bodies of the basidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zealand. The structures of these compounds were determined as the unsymmetrical disulfide cortamidine oxide (1), 2,2 ' -dithiobis(pyridine N-oxide) (2), and the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobial activity and cytotoxicity. 2,2 ' -Dithiobis(pyridine N-oxide) (2) and the symmetrical disulfide 3 are assumed to be artifacts of the isolation procedure.