2-[(2-methylbenzoyl)amino]-4-(pyridin-2-yl)thiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-methylbenzoyl)amino]-4-(pyridin-2-yl)thiazole
• 英文别名: 2-methyl-N-[4-(2-pyridyl)thiazol-2-yl]benzamide；2-methyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzamide
• 化学式: C₁₆H₁₃N₃OS
• 分子量: 295.365
• InChiKey: YIGDUEBFDARPNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴-1-(2-吡啶基)-1-乙酮氢溴酸 在 水 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-[(2-methylbenzoyl)amino]-4-(pyridin-2-yl)thiazole
  参考文献：
  名称：

  Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

  摘要：

  A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the central thiazole moiety and the 2-pyridyl moiety at C-4 of the thiazole are intolerant to modification. However, the N-2 position of the aminothiazole exhibits high flexibility and we successfully improved the antitubercular activity of the initial hit by more than 128-fold through introduction of substituted benzoyl groups at this position. N-(3-Chlorobenzoyl)-4-(2-pyridinyl)-1,3-thiazol-2-amine (55) emerged as one of the most promising analogues with a MIC of 0.024 mu M or 0.008 mu g/mL in 7H9 media and therapeutic index of nearly similar to 300. However, 55 is rapidly metabolized by human liver microsomes (t(1/2) = 28 min) with metabolism occurring at the invariant aminothiazole moiety and Mtb develops spontaneous low-level resistance with a frequency of similar to 10 (5). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.08.048

文献信息

• Whitening Agent And Skin External Preparation
  申请人：Hanyu Naoto

  公开号：US20100324096A1

  公开（公告）日：2010-12-23

  The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein A is C 1-6 alkyl, C 5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C 1-6 alkyl, or C 2-6 alkenyl; “ ” represents a single bond or a double bond wherein n=1 or 2; Y is S or O; and R 3 and R 4 are each independently H, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R 3 is a group other than C 1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R 4 ═Ra═H; X 1 ═X 2 ═CH; and either p =0 or R 5 ═C 1-6 alkyl.

  本发明提供了一种具有优异的抑制黑色素生成作用并且可用作美白剂的化合物，以及含有该化合物的皮肤外用制剂。本发明的美白剂包含以下异构化合物作为活性成分：式（1）或其药学上可接受的盐，其中，A是C1-6烷基、C5-6环烷基、苄基、苯甲酰基、苯甲酰基、苯基、吡啶基或嘧啶基；Ra是氢、C1-6烷基或C2-6烯基；“”表示单键或双键，其中n=1或2；Y是S或O；R3和R4分别独立地是氢、C1-6烷基、羟基-C1-6烷基、C2-7酰基、苯基、吡啶基、嘧啶基等；但当：异杂环含有Y是噻唑环；R4═Ra═H；X1═X2═CH；且p=0或R5═C1-6烷基时，至少一个R3是除了C1-3烷基以外的基团。
• SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN
  申请人：Shiseido Company, Ltd.

  公开号：EP2251001A1

  公开（公告）日：2010-11-17

  The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein A is C1-6 alkyl, C5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C1-6 alkyl, or C2-6 alkenyl; "- - -" represents a single bond or a double bond whereinn = 1 or 2; Y is S or O; and R3 and R4 are each independently H, C1-6 alkyl, hydroxy-C1-6 alkyl, C2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R3 is a group other than C1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R4 = Ra = H; X1 = X2 = CH; and either p = 0 or R5 = C1-6 alkyl.

  本发明提供了一种对黑色素生成具有极佳抑制作用并可用作美白剂的化合物，以及一种含有该化合物的皮肤外用制剂。本发明的美白剂包括作为活性成分的由式（1）代表的杂环化合物或其药理上可接受的盐： 其中 A 是 C1-6 烷基、C5-6 环烷基、苄基、苄氧羰基、苯甲酰基、苯基、吡啶基或嘧啶基；Ra 是 H、C1-6 烷基或 C2-6 烯基；"- - - "代表单键或双键，其中inn = 1 或 2；Y 是 S 或 O；R3 和 R4 各自独立地是 H、C1-6 烷基、羟基-C1-6 烷基、C2-7 丙烯酸基、苯基、吡啶基、嘧啶基等。R3和R4各自独立地为H、C1-6烷基、羟基-C1-6烷基、C2-7酰基、苯基、吡啶基、嘧啶基等；但在以下情况下，至少有一个R3为C1-3烷基以外的基团：含有Y的杂环为噻唑啉环；R4＝Ra＝H；X1＝X2＝CH；p＝0或R5＝C1-6烷基。
• Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis
  作者：Anja Meissner、Helena I. Boshoff、Mahalakshmi Vasan、Benjamin P. Duckworth、Clifton E. Barry、Courtney C. Aldrich

  DOI：10.1016/j.bmc.2013.08.048

  日期：2013.11

  A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the central thiazole moiety and the 2-pyridyl moiety at C-4 of the thiazole are intolerant to modification. However, the N-2 position of the aminothiazole exhibits high flexibility and we successfully improved the antitubercular activity of the initial hit by more than 128-fold through introduction of substituted benzoyl groups at this position. N-(3-Chlorobenzoyl)-4-(2-pyridinyl)-1,3-thiazol-2-amine (55) emerged as one of the most promising analogues with a MIC of 0.024 mu M or 0.008 mu g/mL in 7H9 media and therapeutic index of nearly similar to 300. However, 55 is rapidly metabolized by human liver microsomes (t(1/2) = 28 min) with metabolism occurring at the invariant aminothiazole moiety and Mtb develops spontaneous low-level resistance with a frequency of similar to 10 (5). (C) 2013 Elsevier Ltd. All rights reserved.