司可巴比妥钠 | 309-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 司可巴比妥钠
• 中文别名: 司可巴比妥钠盐；烯戊巴比妥
• 英文名称: Secobarbital-d5, analytical standard, 97 atom % D
• CAS: 309-43-3
• 化学式: C12H18N2NaO3
• 分子量: 261.27
• InChiKey: APVPNHUAMOGOKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

制备方法与用途

制备方法

短效类巴比妥催眠药，作用迅速，服后15分钟即可见效，但作用时间较短，仅持续2-3小时。这类药物主要在肝脏内代谢，并对入睡困难者特别有效，适用于失眠和麻醉前给药。

用途简介

（暂无内容）

文献信息

• AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF
  申请人：Yu Zhenpeng

  公开号：US20140128463A1

  公开（公告）日：2014-05-08

  Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

  本公开涉及酰胺化合物、其制备方法和用途，具体地说，是由式I表示的化合物或药学上可接受的盐，其中R1、R2、R3、R4、R5、Q、X和n的定义如描述中所述。还公开了一种制备式I化合物的方法，含有该化合物的组合物，以及在制备用于调节血脂和/或预防胆结石的药物中使用它的用途。本发明公开的式I化合物在体外具有稳定性，在制药有机溶剂中具有良好的溶解性，并在动物体内具有良好的生物利用度。
• Barbiturate assay, tracers, immunogens and antibodies
  申请人：ABBOTT LABORATORIES

  公开号：EP0373508A2

  公开（公告）日：1990-06-20

  The present invention is directed to a fluorescence polarization immunoassay for barbiturates, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The tracers and the immunogens are made from substituted barbiturate compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane-polarized light that has been passed through a sample containing antiserum and tracer.

  本发明涉及巴比妥类药物的荧光偏振免疫分析法、制备和进行这种分析法所需的各种成分以及制造这些成分的方法。具体而言，本发明公开了示踪剂、免疫原和抗体，以及制备它们的方法。示踪剂和免疫原由取代的巴比妥酸盐化合物制成。示踪剂中含有荧光素分子，免疫原中含有聚氨基酸分子。检测方法是测量平面偏振光通过含有抗血清和示踪剂的样品时的偏振保留程度。
• Preparation of biodegradable microparticles containing a biologically active agent
  申请人：Alkermes Controlled Therapeutics Inc. II

  公开号：EP0998917A1

  公开（公告）日：2000-05-10

  A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.

  一种制备可生物降解微粒的工艺，包括一种可生物降解聚合物粘合剂和一种生物活性剂。由活性剂和聚合物组成的第一阶段和第二阶段通过静态混合器泵入淬火液，形成含有活性剂的微颗粒。最好使用至少两种基本无毒、不含卤代烃的溶剂混合物来溶解或分散活性剂并溶解聚合物。
• PERCUTANEOUSLY ABSORBABLE PREPARATIONS
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1197209A1

  公开（公告）日：2002-04-17

  Percutaneously absorbable preparations (preferably nonaqueous ones, particularly matrix-type patches or ointment), containing salt-form acidic drugs and characterized by being improved in the percutaneous absorbability of the drug by the incorporation of an addition salt of a basic substance therewith and by being lowly irritant to the skin; and a percutaneous absorption accelerator for salt-form acidic drugs, containing an addition salt of a basic substance.

  可经皮吸收的制剂（最好是非水性制剂，特别是基质型贴剂或软膏），含有酸性盐类药物，其特点是通过加入一种碱性物质的添加盐而改善药物的经皮吸收性，并且对皮肤的刺激性低；以及一种酸性盐类药物的经皮吸收促进剂，含有一种碱性物质的添加盐。
• Microparticles
  申请人：Alkermes Controlled Therapeutics Inc. II

  公开号：EP1210942A2

  公开（公告）日：2002-06-05

  The invention provides a particulate material comprising microparticles of a biodegradable biocompatible polymeric matrix containing an active agent and an organic solvent, said organic solvent being present in said microparticles at 2% or less of the total weight of said microparticles.

  本发明提供了一种微粒材料，它由含有活性剂和有机溶剂的可生物降解的生物相容性聚合物基质微粒组成，所述有机溶剂在所述微粒中的含量不超过所述微粒总重量的 2%。