ethyl 3-oxo-3H-2-oxa-fluoranthene-1-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: ethyl 3-oxo-3H-2-oxa-fluoranthene-1-carboxylate
• 英文别名: Ethyl 4-oxo-3-oxatetracyclo[7.6.1.05,16.010,15]hexadeca-1,5(16),6,8,10,12,14-heptaene-2-carboxylate
• 化学式: C₁₈H₁₂O₄
• 分子量: 292.291
• InChiKey: UPQGRFVDJURUNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 生成 ethyl 3-oxo-3H-2-oxa-fluoranthene-1-carboxylate
  参考文献：
  名称：

  Construction of Heterocyclic Compounds by Use of α-Diazophosphonates:  New One-Pot Syntheses of Indoles and Isocoumarins

  摘要：

  [GRAPHICS]alpha-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding alpha-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.

  DOI：

  10.1021/ol025916k

文献信息

• Construction of Heterocyclic Compounds by Use of α-Diazophosphonates:  New One-Pot Syntheses of Indoles and Isocoumarins
  作者：Yoshinori Nakamura、Tatsuzo Ukita

  DOI：10.1021/ol025916k

  日期：2002.7.1

  [GRAPHICS]alpha-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding alpha-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.