Functionalized pyridine carbamates with enhanced neuroprotective activity
申请人:Texas Tech University System
公开号:US11369593B2
公开(公告)日:2022-06-28
The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.
Functionalized Pyridine Carbamates with Enhanced Neuroprotective Activity
申请人:Texas Tech University System
公开号:US20210023064A1
公开(公告)日:2021-01-28
The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.
[EN] FUNCTIONALIZED PYRIDINE CARBAMATES WITH ENHANCED NEUROPROTECTIVE ACTIVITY<br/>[FR] CARBAMATES DE PYRIDINE FONCTIONNALISÉS PRÉSENTANT UNE ACTIVITÉ NEUROPROTECTRICE AMÉLIORÉE
申请人:UNIV TEXAS TECH SYSTEM
公开号:WO2019014547A1
公开(公告)日:2019-01-17
The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.
Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)
作者:Nihar Kinarivala、Ronak Patel、Rose-Mary Boustany、Abraham Al-Ahmad、Paul C. Trippier
DOI:10.1021/acs.jmedchem.7b01199
日期:2017.12.14
etoposide-induced apoptosis at concentrations as low as 100 nM. The developed aromaticcarbamates possess physicochemical properties desirable for CNS therapeutics. The primary known mechanisms of action of the parent scaffold are not responsible for the observed neuroprotective activity. Herein, we demonstrate that neuroprotective aromaticcarbamates function to increase the Bcl-2/Bax ratio to an antiapoptotic state