2-[(3R)-oxolan-3-yl]acetyl chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-[(3R)-oxolan-3-yl]acetyl chloride
• 化学式: C₆H₉ClO₂
• 分子量: 148.59
• InChiKey: CRFMRVSWUCYNRC-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(3R)-oxolan-3-yl]acetyl chloride 、 5-[1-(2-methyl-1H-imidazol-1-yl)ethyl]pyrazin-2-amine dihydrochloride 在 吡啶 、 4-二甲氨基吡啶 作用下， 以74.2 %的产率得到(R)-N-(5-(1-(2-methyl-1H-imidazol-1-yl)ethyl)pyrazin-2-yl)-2-((R)-tetrahydrofuran-3-yl)acetamide
  参考文献：
  名称：

  HETEROAROMATIC COMPOUNDS

  摘要：

  The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as chemotherapy induced peripheral neuropathy (CIPN).

  公开号：

  WO2024126777A1

文献信息

• HETEROAROMATIC COMPOUNDS
  申请人：[en]ASTRAZENECA AB

  公开号：WO2024126777A1

  公开（公告）日：2024-06-20

  The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as chemotherapy induced peripheral neuropathy (CIPN).