(4bSR,9SR,9aSR)-7-methoxy-9,4b-diphenyl-10,11,4b,9a-tetrahydrobenzo[c]fluoren-6-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (4bSR,9SR,9aSR)-7-methoxy-9,4b-diphenyl-10,11,4b,9a-tetrahydrobenzo[c]fluoren-6-ol
• 英文别名: (6aS,7R,11bS)-9-methoxy-7,11b-diphenyl-5,6,6a,7-tetrahydrobenzo[c]fluoren-10-ol
• 化学式: C₃₀H₂₆O₂
• 分子量: 418.535
• InChiKey: XBWHBOGWOHZMSA-LQJQRVQGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(hydroxy(phenyl)methyl)-2-methoxyphenol 、 3,4-二氢-1-苯基萘 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以40%的产率得到(4bSR,9SR,9aSR)-7-methoxy-9,4b-diphenyl-10,11,4b,9a-tetrahydrobenzo[c]fluoren-6-ol
  参考文献：
  名称：

  A Formal [3 + 2] Alkene Addition to Benzhydrol Cations. A Practical and Mild Methodology for the Synthesis of Substituted 1‐Arylindanes and Related Compounds

  摘要：

  We report the single step synthesis of several 1-arylindanes in good yield via a formal [3 + 2] atom cycloaddition. The success of this formal cycloaddition relies on the Lewis acid activation of a bibenzylic alcohol in the presence of an alkene. The cation generated from the alcohol can be trapped by the alkene to afford a new benzylic cation which can then undergoes cyclization leading to 1-arylindanes with three stereogenic centres.

  DOI：

  10.1081/scc-120027710

文献信息

• A Formal [3 + 2] Alkene Addition to Benzhydrol Cations. A Practical and Mild Methodology for the Synthesis of Substituted 1‐Arylindanes and Related Compounds
  作者：Beatriz Lantaño、Jose M. Aguirre、Liliana Finkielsztein、Elba N. Alesso、Ernesto Brunet、Graciela Y. Moltrasio

  DOI：10.1081/scc-120027710

  日期：2004.12.31

  We report the single step synthesis of several 1-arylindanes in good yield via a formal [3 + 2] atom cycloaddition. The success of this formal cycloaddition relies on the Lewis acid activation of a bibenzylic alcohol in the presence of an alkene. The cation generated from the alcohol can be trapped by the alkene to afford a new benzylic cation which can then undergoes cyclization leading to 1-arylindanes with three stereogenic centres.