2,3-dihydroxy-6-methyl-benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-dihydroxy-6-methyl-benzoic acid
• 英文别名: 5.6-Dioxy-2-methyl-benzol-carbonsaeure-(1)；2,3-Dihydroxy-6-methyl-benzoesaeure；5.6-Dioxy-o-toluylsaeure；Berberinsaeure；2,3-Dihydroxy-6-methylbenzoic acid
• 化学式: C₈H₈O₄
• 分子量: 168.149
• InChiKey: XVFMTWMMWSPTEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-dihydroxy-6-methyl-benzoic acid 生成 3,4-二羟基甲苯
  参考文献：
  名称：

  Education and Advertising:

  摘要：

  生产卫生用品的制造商出版的教育小册子已经被用来教授几代女孩有关月经的知识。这些小册子的普及和重要性使它们成为月经态度的潜在重要贡献者。本研究分析了1932年至1997年间商业生产的28份小册子的内容。检查了小册子中呈现的信息质量，以确定后期小册子是否比早期小册子包含更准确和积极的信息。后期小册子不太可能将月经描绘为卫生危机，但同样可能推广保密。它们也更有可能在插图中描绘种族多样性，并且不太可能对女孩家庭的构成做出假设。通过呈现准确、平衡和适合发展阶段的教育材料，可以增加青少年的知识。

  DOI：

  10.1177/027243102237192
• 作为产物：
  描述：

  Berberinol 在 氢氧化钾 作用下， 生成 2,3-dihydroxy-6-methyl-benzoic acid
  参考文献：
  名称：

  Perkin, Journal of the Chemical Society, 1889, vol. 55, p. 71

  摘要：

  DOI：

文献信息

• Soluble late transition metal catalysts for olefin oligomerizations III
  申请人：Zhao Baiyi

  公开号：US20060036049A1

  公开（公告）日：2006-02-16

  A series of soluble α-diimine late transition metal catalysts has been invented comprising a substituted or unsubstituted catecholate ligand. The catalysts demonstrate high activity and selectivity for linear α-olefins. As such, these catalysts conveniently oligomerize ethylene. Typical activators as known to those of ordinary skill in the art are used to activate these transition metal catalysts. These catalysts can be used in a supported or unsupported form.

  一系列可溶性的α-二亚胺后过渡金属催化剂已经被发明，其中包括取代或未取代的邻苯二酚配体。这些催化剂表现出高活性和线性α-烯烃的高选择性。因此，这些催化剂方便地可以使乙烯寡聚化。通常的活化剂，如对于普通技术人员而言是已知的，被用来激活这些过渡金属催化剂。这些催化剂可以以支持或不支持的形式使用。
• Late transition metal catalysts for olefin polymerization and oligomerization
  申请人：Cherkasov Kuzunich Vladimir

  公开号：US20060047094A1

  公开（公告）日：2006-03-02

  This invention relates to a transition metal compound represented by the formula LMX wherein M is a Group 3 to 11 metal L is a bulky bidentate or tridentate neutral ligand that is bonded to M by two or three heteroatoms and at least one heteroatom is nitrogen; X is a substituted or unsubstituted catecholate ligand provided that the substituted catecholate ligand does not contain a 1,2-diketone functionality.

  本发明涉及一种由式LMX所表示的过渡金属化合物，其中M是第3到11族金属，L是一种笨重的双或三齿中性配体，通过两个或三个杂原子与M结合，至少一个杂原子是氮；X是一种取代或未取代的邻二酚配体，但取代的邻二酚配体不含1,2-二酮官能团。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• Cephalosporin derivatives, processes for the preparation of the same, intermediates for use in the synthesis of the same, pharmaceutical compositions comprisingthe same, and the use of the same for the manufacture of a medicament having valuable therapeutic and preventative properties
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0269087A2

  公开（公告）日：1988-06-01

  The present invention relates to cephalosporin derivatives, processes for the preparation thereof, pharmaceutical compositions comprising such derivatives, compounds for use as intermediates in the synthesis of such derivatives and processes for producing thereof, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic and preventative properties. The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a carboxy and hydroxy substituted phenylmethyloxyimino moiety, particularly a (carboxy substituted catechol)methyloxyimino moiety, as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

  本发明涉及头孢菌素衍生物、其制备工艺、包含此类衍生物的药物组合物、用作合成此类衍生物的中间体的化合物及其生产工艺，以及使用此类衍生物制造具有重要治疗和预防特性的药物。 本发明的基础是选择含有缩合杂环（特别是三唑并嘧啶环）的基团作为头孢骨架 3 位的取代基，并选择含有羧基和羟基取代的苯基甲氧基亚氨基（特别是（羧基取代的儿茶酚）甲氧基亚氨基）的基团作为头孢骨架 7 位的取代基。 含有上述取代基的本发明化合物对革兰氏阴性菌和革兰氏阳性菌（包括耐甲氧西林金黄色葡萄球菌）具有很强的抗菌活性。这些化合物对治疗传染性疾病极为有用。
• Bernheimer, Gazzetta Chimica Italiana, 1883, vol. 13, p. 343
  作者：Bernheimer

  DOI：——

  日期：——