吗啡单水合物 | 6009-81-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 中文名称: 吗啡单水合物
• 英文名称: morphine hydrate
• 英文别名: morphine monohydrate；(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrate
• CAS: 6009-81-0
• 化学式: C₁₇H₁₉NO₃*H₂O
• 分子量: 303.358
• InChiKey: IYXRQFVHZFEWSY-VYKNHSEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  53.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  吗啡单水合物 生成 阿扑吗啡
  参考文献：
  名称：

  WO2007126659A1

  摘要：

  公开号：

文献信息

• [EN] SYNTHESIS OF MORPHINE AND RELATED DERIVATIVES<br/>[FR] SYNTHÈSE DE LA MORPHINE ET DE DÉRIVÉS ASSOCIÉS
  申请人：UNIV TEXAS

  公开号：WO2010132570A1

  公开（公告）日：2010-11-18

  The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof, wherein the starting compound is biphenyl.

  本发明涉及一种合成迷迭香碱、吗啡、中间体、盐和衍生物的方法，其中起始化合物为联苯。
• SYNTHESIS OF MORPHINE-6-GLUCURONIDE OR ONE OF THE DERIVATIVES THEREOF
  申请人：DLUBALA Alain

  公开号：US20110275820A1

  公开（公告）日：2011-11-10

  The disclosure relates to a method for preparing morphine-6-glucuronide or one of the deritives thereof comprising reacting a compound of formula (I): wherein R 1 is as defined in the disclosure, with a glucuronic acid derivative of formula (II): wherein PG, X, and R 4 are as defined in the disclosure, in the presence of an aromatic solvent and trimethylsilyl trifluoromethanesulfonate; (ii) reacting the product obtained in step (i) with a strong basic agent; and then (iii) recovering the product obtained in step (ii).

  披露涉及一种制备吗啡-6-葡糖苷或其衍生物之一的方法，包括将式(I)的化合物： 其中R1如披露中定义， 与式(II)的葡糖酸衍生物： 其中PG、X和R4如披露中定义， 在芳香溶剂和三甲基硅基三氟甲磺酸酯的存在下反应； (ii) 用强碱性试剂处理步骤(i)中获得的产物；然后(iii)回收步骤(ii)中获得的产物。
• [EN] CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF<br/>[FR] TRANSFORMATIONS CHIMIQUES DE (-)-CODÉINE POUR FOURNIR DES DÉRIVÉS DE CODÉINE ET DE MORPHINE CORRESPONDANTS
  申请人：UNIV TEXAS

  公开号：WO2013184902A1

  公开（公告）日：2013-12-12

  The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions.

  本发明涉及吗啡、可待因、中间体、盐及其衍生物的合成方法。在优选实施方式中，本发明涉及改善所述可待因和吗啡相关衍生物及其中间体的效率、立体选择性和总产率的方法。本发明涉及新的可待因和吗啡相关衍生物组合物。
• Process for Making Apomorphine and Apocodeine
  申请人：Gurusamy Narayanasamy

  公开号：US20100228032A1

  公开（公告）日：2010-09-09

  There is provided an improved and convenient process for the synthesis of aporphines, such as apomorphine and apocodeine, by the rearrangement of the corresponding morphine or codeine derivatives. The use of a suitable water scavenger in an acid catalyzed rearrangement of the morphine derivatives unexpectedly results in a reaction temperature convenient for plant operation without sacrificing product. The method of the present invention also alleviates the cumbersome operations that were employed in the prior art to eliminate water from the reaction mixture at the elevated temperatures. This process is adaptable for the general preparation of other aporphines from the corresponding morphine congeners.

  提供了一种改进和便利的合成阿泼吗啡(apomorphine)和阿泼可定(apocodeine)等阿泼啡(aporphines)的方法，该方法通过对应的吗啡(morphine)或可待因(codeine)衍生物的重排来实现。在酸催化的吗啡衍生物重排中使用适当的水清除剂，出乎意料地得到了适合植物操作的反应温度，而不会牺牲产品。本发明方法还减轻了在先前的技术中用于在高温下从反应混合物中消除水的繁琐操作。该过程适用于从相应的吗啡同系物中普遍制备其他阿泼啡的方法。
• Efficient Synthesis Of Morphine And Codeine
  申请人：Magnus Philip D.

  公开号：US20100292475A1

  公开（公告）日：2010-11-18

  The present invention relates to methods for the synthesis of morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

  本发明涉及吗啡、中间体、盐和衍生物的合成方法。在优选实施例中，本发明涉及改善吗啡、吗啡相关衍生物和中间体的效率和总产量的方法。在进一步实施例中，本发明涉及改善迷迭香碱及其中间体的效率和总产量的方法。