formanilide; hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: formanilide; hydrochloride
• 英文别名: Formanilid; Hydrochlorid；Formyl(phenyl)azanium;chloride；formyl(phenyl)azanium;chloride
• 化学式: 2C₇H₇NO*ClH
• 分子量: 278.738
• InChiKey: DMGREGPSYASHFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-苯基甲酰胺 在 盐酸 、 xylene 作用下， 生成 formanilide; hydrochloride
  参考文献：
  名称：

  Schmidt,O., Chemische Berichte, 1903, vol. 36, p. 2481

  摘要：

  DOI：

文献信息

• Process for the production of di-and polyamines of the diphenylmethane series
  申请人：HUNTSMAN INTERNATIONAL LLC

  公开号：EP2039676A1

  公开（公告）日：2009-03-25

  Process for the production of di- and poly( diamino diphenyl methane) comprising the steps of (a) reacting aniline and formaldehyde in the presence of an acid catalyst to produce a reaction mixture containing di- and polyamines; (b) neutralising the reaction mixture containing di- and polyamines; (c) separating the neutralised reaction mixture into an organic phase containing di- and polyamines and an aqueous phase; (d) further treating the organic phase separated off in step (c) by (d1) washing with water followed by (d2) separating the washed mixture into an organic phase and an aqueous phase and (d3) further fractionation of the organic phase to produce purified di- and polyamines on the one hand and aniline/water on the other hand; (e) further treating the aqueous phase separated off in step (c) by (e1) washing with aniline followed by (e2) separating the washed mixture into an aqueous phase and an organic phase and (e3) further treatment of the aqueous phase to remove the aniline thereby leaving an effluent stream wherein phase separation in step (c) and/or step (e2) is facilitated by using any of the following methods either on its own or in combination with one or more of the other methods: (A) removal of some of the water from the neutralised reaction mixture obtained in step (b) or the aqueous phase separated in step (c); (B) addition of inorganic salt to the neutralised reaction mixture obtained in step (b); (C) return of some of the aqueous phase obtained in step (e2) or (e3) to the neutralised reaction mixture obtained in step (b) or to the washed mixture in step (e1).

  生产二氨基和多氨基二苯甲烷的工艺，包括以下步骤 (a) 在酸催化剂存在下，使苯胺和甲醛反应，生成含有二胺和多胺的反应混 合物； (b) 中和含有二胺和多胺的反应混合物 (c) 将中和后的反应混合物分离成含有二胺和多胺的有机相和水相； (d) 进一步处理在步骤(c)中分离出的有机相：(d1) 用水洗，然后 (d2) 将水洗混合物分离成有机相和水相；(d3) 进一步分馏有机相，一方面产生纯化的二胺和多胺，另一方面产生苯胺/水； (e) 进一步处理步骤(c)中分离出的水相，(e1)用苯胺洗涤，(e2)将洗涤后的混合物分离成水相和有机相，(e3)进一步处理水相以除去苯胺，从而留下流出液，其中步骤(c)和/或步骤(e2)中的相分离可通过单独使用或与一种或多种其他方法结合使用以下任一方法来实现： (A) 从步骤（b）得到的中和反应混合物或步骤（c）分离的水相中去除部分水； (B) 向步骤（b）中得到的中和反应混合物中添加无机盐； (C) 将步骤(e2)或(e3)中得到的部分水相返回步骤(b)中得到的中和反应混合物或步骤(e1)中得到的洗涤混合物。
• Wheeler; Barnes; Pratt, American Chemical Journal, 1897, vol. 19, p. 681
  作者：Wheeler、Barnes、Pratt

  DOI：——

  日期：——
• PROCESS FOR THE PRODUCTION OF DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES
  申请人：Huntsman International LLC

  公开号：EP2203407B1

  公开（公告）日：2016-11-16
• PROCESS FOR PRODUCTION OF DI- AND POLYAMINES OF THE DIPHENYLMETHANE SERIES
  申请人：Carr Robert

  公开号：US20110263809A1

  公开（公告）日：2011-10-27

  Process for the production of di- and poly(diamino diphenyl methane) comprising the steps of (a) reacting aniline and formaldehyde in the presence of an acid catalyst to produce a reaction mixture containing di- and polyamines; (b) neutralising the reaction mixture containing di- and polyamines; (c) separating the neutralised reaction mixture into an organic phase containing di- and polyamines and an aqueous phase; (d) further treating the organic phase separated off in step (c) by (d1) washing with water followed by (d2) separating the washed mixture into an organic phase and an aqueous phase and (d3) further fractionation of the organic phase to produce purified di- and polyamines on the one hand and aniline/water on the other hand; (e) further treating the aqueous phase separated off in step (c) by (e1) washing with aniline followed by (e2) separating the washed mixture into an aqueous phase and an organic phase and (e3) further treatment of the aqueous phase to remove the aniline thereby leaving an effluent stream wherein phase separation in step (c) and/or step (e2) is facilitated by using any of the following methods either on its own or in combination with one or more of the other methods: (A) removal of some of the water from the neutralised reaction mixture obtained in step (b) or the aqueous phase separated in step (c); (B) addition of inorganic salt to the neutralised reaction mixture obtained in step (b) or the aqueous phase separated in step (c); (C) return of some of the aqueous phase obtained in step (e2) or (e3) to the neutralised reaction mixture obtained in step (b) or to the washed mixture in step (e1).
• US9217054B2
  申请人：——

  公开号：US9217054B2

  公开（公告）日：2015-12-22