(2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)-3-phenylpropane-1,2-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)-3-phenylpropane-1,2-diamine
• 化学式: C₁₃H₁₉N₄PolS₂
• 分子量: 344.5
• InChiKey: QZQLIEMKLAQPMV-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)-3-phenylpropane-1,2-diamine 在 氢氟酸 作用下， 反应 1.5h， 生成
  参考文献：
  名称：

  Synthesis of Chiral Polyaminothiazoles

  摘要：

  An efficient approach toward the parallel solid-phase synthesis of highly diversified chiral polyaminothiazoles employing Hantzsc’s thiazole synthesis is presented. The treatment of resin-bound chiral polyamines with Fmoc-isothiocyanates generated polythioureas which were further reacted with a variety of α-halogenoketones to afford following cleavage from the solid support the desired chiral polyaminothiazoles in good yield and purity.

  DOI：

  10.1021/cc9001907

文献信息

• Synthesis of Chiral Polyaminothiazoles
  作者：Sergey Arutyunyan、Adel Nefzi

  DOI：10.1021/cc9001907

  日期：2010.5.10

  An efficient approach toward the parallel solid-phase synthesis of highly diversified chiral polyaminothiazoles employing Hantzsc’s thiazole synthesis is presented. The treatment of resin-bound chiral polyamines with Fmoc-isothiocyanates generated polythioureas which were further reacted with a variety of α-halogenoketones to afford following cleavage from the solid support the desired chiral polyaminothiazoles in good yield and purity.