1-(anthracen-9-ylmethyl)-1,4,7-triazonane

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-(anthracen-9-ylmethyl)-1,4,7-triazonane
• 英文别名: 1-(9-methylanthracenyl)-1,4,7-triazacyclononane；1-(Anthracen-9-ylmethyl)-1,4,7-triazonane
• 化学式: C₂₁H₂₅N₃
• 分子量: 319.45
• InChiKey: SBLUHRDDGCZVEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(anthracen-9-ylmethyl)-1,4,7-triazonane 、 间二溴苄 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以80%的产率得到4,4'-m-xylylenebis[1-(9-methylanthracenyl)-1,4,7-triazacyclononane]
  参考文献：
  名称：

  Blǎniţǎ, Gabriela; Buçsa, Monica; Coroş, Maria, Revue Roumaine de Chimie, 2008, vol. 53, # 1, p. 15 - 19

  摘要：

  DOI：
• 作为产物：
  描述：

  9-氯甲基蒽 、 1,4,7-三氮杂环壬烷 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 生成 1-(anthracen-9-ylmethyl)-1,4,7-triazonane
  参考文献：
  名称：

  RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE

  摘要：

  提供了一种用于检测体内硫化氢的探针，具体来说，是一种用于检测硫化氢的探针，其中包括引入了放射性同位素铜的复合物。根据本公开的具体实施例，通过实时观察动物模型，可以大量生成涉及各种疾病的硫化氢，通过光学和核医学成像，根据本公开的检测硫化氢的探针可以选择性地与硫化氢结合，提供细胞或组织中硫化氢异常增加的部位的图像，从而在不影响身体解剖特性的情况下检测意外部位的疾病。此外，用于检测硫化氢的探针与硫化氢迅速反应，从而解决了注射成像剂后等待预定时间进行测试的现有问题。因此，该探针可以有效用作诊断疾病的手段，如成像组合物、成像方法等。

  公开号：

  EP3281643A2

文献信息

• Radioactive probe for detecting hydrogen sulfide
  申请人：KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US10583206B2

  公开（公告）日：2020-03-10

  Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.

  本发明提供了一种用于检测体内硫化氢的探针，具体地说，是一种用于检测硫化氢的探针，包括一种引入放射性同位素Cu的复合化合物。根据本公开的具体实施例，由于通过光学和核医学成像实时观察动物模型，其中涉及各种疾病的硫化氢大量产生，根据本公开的用于检测硫化氢的探针可选择性地与硫化氢结合，提供硫化氢在细胞或组织中异常增加的部位的图像，从而在不影响人体解剖学特性的情况下检测意外部位的疾病。因此，该探针可有效地用作诊断疾病的手段，如成像组合物、成像方法等。
• [EN] RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE<br/>[FR] SONDE RADIOACTIVE POUR LA DÉTECTION DE SULFURE D'HYDROGÈNE<br/>[KO] 황화수소 검출용 방사성 프로브
  申请人：KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND

  公开号：WO2016163727A2

  公开（公告）日：2016-10-13

  본 발명은 생체 내 황화수소 검출용 프로브에 관한 것으로서, 구체적으로는 방사성 동위원소 Cu가 도입된 착화합물을 포함하는 황화수소 검출용 프로브에 관한 것이다. 본 발명의 여러 구현예에 따르면, 다양한 질병에 관여하고 있는 황화수소가 많이 발생한 동물 모델을 이용하여 광학, 핵의학 영상 등을 통해 실시간 관찰한 결과, 본 발명에 따른 황화수소 검출용 프로브는 황화수소와 선택적으로 결합하여, 세포 또는 조직 내에서 황화수소가 비정상적으로 증가된 부위를 선택적으로 영상화할 수 있어, 신체 부위의 해부학적 특성에 영향을 주지 않으므로 전혀 예측하지 못한 부분의 질병도 발견할 수 있을 뿐만 아니라, 상기 황화수소 검출용 프로브는 황화수소와 반응 속도가 빨라 종래 영상화제 투여 후 일정시간이 지난 다음 검사를 하는 문제점을 해결할 수 있으므로 영상화용 조성물 또는 영상화 방법 등 질병 진단 수단으로 유용하게 이용될 수 있다.
• Blǎniţǎ, Gabriela; Buçsa, Monica; Coroş, Maria, Revue Roumaine de Chimie, 2008, vol. 53, # 1, p. 15 - 19
  作者：Blǎniţǎ, Gabriela、Buçsa, Monica、Coroş, Maria、Vlassa, Mircea

  DOI：——

  日期：——
• RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE
  申请人：Kyungpook National University Industry-Academic Cooperation Foundation

  公开号：EP3281643A2

  公开（公告）日：2018-02-14

  Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.

  提供了一种用于检测体内硫化氢的探针，具体来说，是一种用于检测硫化氢的探针，其中包括引入了放射性同位素铜的复合物。根据本公开的具体实施例，通过实时观察动物模型，可以大量生成涉及各种疾病的硫化氢，通过光学和核医学成像，根据本公开的检测硫化氢的探针可以选择性地与硫化氢结合，提供细胞或组织中硫化氢异常增加的部位的图像，从而在不影响身体解剖特性的情况下检测意外部位的疾病。此外，用于检测硫化氢的探针与硫化氢迅速反应，从而解决了注射成像剂后等待预定时间进行测试的现有问题。因此，该探针可以有效用作诊断疾病的手段，如成像组合物、成像方法等。