吡咯烷,3-十二基-1-丙基- | 137909-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 吡咯烷,3-十二基-1-丙基-
• 英文名称: Pyrrolidine, 3-dodecyl-1-propyl-
• 英文别名: 3-dodecyl-1-propylpyrrolidine
• CAS: 137909-16-1
• 化学式: C₁₉H₃₉N
• 分子量: 281.5
• InChiKey: AOQKMOMSMNEVLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Topical pharmaceutical composition to treat hyperpigmentation of the skin
  申请人：——

  公开号：US20030072724A1

  公开（公告）日：2003-04-17

  Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

  本发明提供了一种用于美白皮肤的外用药物组合物，该组合物尤其适用于治疗皮肤色素沉着，同时还提供了其使用方法。该组合物和方法涉及局部使用一种有效治疗皮肤色素沉着的活性剂和一种渗透增强基剂，在一个实施方案中，该基剂使组合物的 pH 值约为 8.0 至约 13.0，优选约为 8.0 至 11.5，最优选约为 8.5 至 10.5。
• Method and topical formulation for treating skin conditions associated with aging
  申请人：——

  公开号：US20030059450A1

  公开（公告）日：2003-03-27

  A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation has a pH in the range of about 7.5 to 13.0, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either a hydroxide-releasing agent, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid, or is an organic base, particularly a nitrogenous base.

  本发明提供了一种组合物和方法，用于减轻内在和外在衰老的皮肤病症状。将含有药用活性基的外用制剂（其中制剂的 pH 值在 7.5 至 13.0 之间）涂抹在皮肤上，以预防或治疗与衰老有关的皮肤病，如皱纹、皮肤干燥、老年斑、日光损伤（特别是紫外线辐射引起的氧化应激）、斑点、皮肤色素沉着、老年斑、皮肤厚度增加、皮肤弹性和胶原蛋白含量下降、皮肤干燥、色斑和黑斑。化妆品活性碱可以是氢氧化物释放剂，如无机氢氧化物、无机氧化物或弱酸的金属盐，也可以是有机碱，特别是含氮碱。
• Topical pharmaceutical composition for the treatment of warts
  申请人：——

  公开号：US20030072814A1

  公开（公告）日：2003-04-17

  Provided is a topical pharmaceutical composition for the treatment of warts, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of warts plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. This composition can be used to treat human papilloma virus infections, particularly cutaneous warts.

  本发明提供了一种治疗尖锐湿疣的外用药物组合物及其使用方法。该组合物和方法涉及局部使用一种有效治疗尖锐湿疣的活性剂和一种渗透增强基质，在一个实施方案中，该基质使组合物的 pH 值约为 8.0 至约 13.0，优选约为 8.0 至 11.5，最优选约为 8.5 至 10.5。这种组合物可用于治疗人类乳头瘤病毒感染，特别是皮肤疣。
• Topical pharmaceutical composition for the treatment of inflammatory dermatoses
  申请人：——

  公开号：US20030077301A1

  公开（公告）日：2003-04-24

  Provided is a topical pharmaceutical composition for the treatment of inflammatory dermatoses, including acne vulgaris, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of inflammatory dermatoses plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

  本文提供了一种用于治疗炎症性皮肤病（包括寻常痤疮）的外用药物组合物及其使用方法。该组合物和方法涉及局部使用一种有效治疗炎症性皮肤病的活性剂和一种渗透增强基质，在一个实施方案中，该基质使组合物的 pH 值为约 8.0 至约 13.0，优选约 8.0 至 11.5，最优选约 8.5 至 10.5。
• Topical administration of pharmacologically active bases for skin lightening
  申请人：——

  公开号：US20030235542A1

  公开（公告）日：2003-12-25

  Provided are methods and topical pharmaceutical formulations for skin lightening. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat regions of hyperpigmented skin, comprising, as examples, age spots, freckles, disease-related hyperpigmented skin, melasma related to pregnancy or the use of oral contraceptives, and hyperpigmented skin due to chemical exposure or ingestion.

  本发明提供了美白皮肤的方法和外用药物制剂。本发明涉及在 pH 值约为 7.5 至约 13.0，优选约为 8.0 至 11.5，最优选约为 8.5 至 10.5 的制剂中局部施用药理活性基质。这些基本制剂可用于治疗皮肤色素沉着区域，例如老年斑、雀斑、与疾病相关的色素沉着皮肤、与怀孕或使用口服避孕药相关的黄褐斑，以及因接触或摄入化学物质而导致的色素沉着皮肤。