吡哆醛5'-硫酸酯 | 40225-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 吡哆醛5'-硫酸酯
• 英文名称: Pyridoxalbetainsulfonsaeure
• 英文别名: Pyridoxalsulfat；Pyridoxal-5'-sulfat；Pyridoxal 5'-sulfate；(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl hydrogen sulfate
• CAS: 40225-35-2
• 化学式: C₈H₉NO₆S
• 分子量: 247.229
• InChiKey: OJQQRWWUNXTWER-UHFFFAOYSA-N

物化性质

• 密度：
  1.645±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Oxygen carrier
  申请人：AJINOMOTO CO., INC.

  公开号：EP0067029A2

  公开（公告）日：1982-12-15

  A modified haemoglobin for use as an oxygen carrier in a blood substitute is prepared by covalently bonding haemoglobin or a haemoglobin derivative to a polyalkylene glycol, via an amide bond. A carboxyl group is first introduced onto the polyalkylene glycol, and is then reacted with an amino group of the haemoglobin or haemoglobin derivative to form the amide bond.

  通过酰胺键将血红蛋白或血红蛋白衍生物与聚亚烷基二醇共价键合，可制备用作血液替代品中氧载体的改性血红蛋白。首先在聚亚烷基二醇上引入一个羧基，然后与血红蛋白或血红蛋白衍生物的氨基反应形成酰胺键。
• Nitrogen monoxide metabolite-polyoxyalkylene-hemoglobin complex
  申请人：HOKKAIDO UNIVERSITY

  公开号：EP1029551A2

  公开（公告）日：2000-08-23

  Disclosed is a nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex having a molecular weight of from 100,000 to 2,000,000 daltons, in which a polyoxyalkylene derivative is bound to from 10 to 30% in total of bindable amino groups in hemoglobin and a nitric monoxide metabolite is bound to from 10 to 100% in total of thiol groups of cysteine residues.

  本发明公开了一种一氧化氮代谢物-聚氧亚烷基-血红蛋白复合物，其分子量为 100,000 至 2,000,000 道尔顿，其中聚氧亚烷基衍生物与血红蛋白中总计 10% 至 30% 的可结合氨基结合，一氧化氮代谢物与半胱氨酸残基总计 10% 至 100% 的硫醇基结合。
• Preparation containing an oxygen carrier for regeneration of the skin in the case of oxygen deficiency
  申请人：——

  公开号：US20030180365A1

  公开（公告）日：2003-09-25

  The invention relates to an oxygen carrier-containing preparation, which can be applied externally, hemoglobin and optionally myoglobin being incorporated in a preparation in a gel-like consistency. The preparation is suitable for being rubbed into the skin in order to intensify the diffusive supply of oxygen to the skin from the outside in order to regenerate the skin and eliminate the oxygen deficiency. The agent is also suitable for preventing such conditions and is particularly suitable in the case of degenerative, radiation-induced, thermally induced and age-related skin changes, even after the skin has suffered burns, optionally in co-therapy with intravasal oxygen therapy. The invention furthermore relates to a method for preparing such a preparation and to its use.

  本发明涉及一种可外用的含氧载体制剂，血红蛋白和可选的肌红蛋白被纳入一种凝胶状制剂中。该制剂适用于擦拭皮肤，以加强氧气从外部向皮肤的扩散供应，从而使皮肤再生并消除缺氧现象。该制剂还适用于预防此类病症，尤其适用于退行性、辐射诱导、热诱导和与年龄有关的皮肤变化，甚至在皮肤遭受烧伤之后，可选择与侵入性氧疗法联合治疗。 本发明还涉及制备这种制剂的方法及其用途。
• Modified hemoglobins suitable for use as oxygen carriers for blood substitutes
  申请人：AJINOMOTO CO., INC.

  公开号：EP0043675B1

  公开（公告）日：1984-10-03
• Hemoglobin combined with a poly(alkylene oxide)
  申请人：AJINOMOTO CO., INC.

  公开号：EP0206448B1

  公开（公告）日：1990-11-14