2-methoxy-5-((5,6,7-trimethoxy-4-oxochroman-3-yl)-methyl)phenyl (tert-butoxycarbonyl)-L-phenylalaninate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: 2-methoxy-5-((5,6,7-trimethoxy-4-oxochroman-3-yl)-methyl)phenyl (tert-butoxycarbonyl)-L-phenylalaninate
• 英文别名: SH-11037；[2-methoxy-5-[(5,6,7-trimethoxy-4-oxo-2,3-dihydrochromen-3-yl)methyl]phenyl] (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoate
• 化学式: C₃₄H₃₉NO₁₀
• 分子量: 621.684
• InChiKey: WNDLJGVBWVLFKK-WCSIJFPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯酚 在 4-二甲氨基吡啶 、 甲酸 、 palladium on activated charcoal 、 三氟化硼乙醚 、 水 、 sodium formate 、 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 potassium hydroxide 、 sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 异丙醇 为溶剂， 反应 91.0h， 生成 2-methoxy-5-((5,6,7-trimethoxy-4-oxochroman-3-yl)-methyl)phenyl (tert-butoxycarbonyl)-L-phenylalaninate
  参考文献：
  名称：

  [EN] COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES
  [FR] COMPOSÉS POUR TRAITER DES MALADIES MÉDIÉES PAR L'ANGIOGENÈSE

  摘要：

  披露了合成克雷马斯特罗内和克雷马斯特罗内类似物。此外，还披露了合成克雷马斯特罗内和克雷马斯特罗内类似物的方法。还披露了治疗眼部新生血管疾病和治疗血管生成介导的疾病的方法。

  公开号：

  WO2014182695A1

文献信息

• COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES
  申请人：INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION

  公开号：US20160060241A1

  公开（公告）日：2016-03-03

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  本文介绍了合成人造的cremastranone和类似物的方法。此外，还介绍了合成cremastranone和cremastranone类似物的方法。还介绍了治疗眼部新生血管疾病和治疗血管生成介导的疾病的方法。
• Compounds for treatment of angiogenesis-mediated diseases
  申请人：Indiana University Research and Technology Corporation

  公开号：US10238627B2

  公开（公告）日：2019-03-26

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  本发明公开了合成的 cremastranone 和 cremastranone 类似物。此外，还公开了合成 cremastranone 和 cremastranone 类似物的方法。还公开了治疗眼部新生血管疾病和治疗血管生成介导疾病的方法。
• COMPOSITION FOR BLOCKING ANGIOGENESIS
  申请人：Indiana University Research and Technology Corporation

  公开号：US20210228538A1

  公开（公告）日：2021-07-29

  Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.
• SOLUBLE EPOXIDE HYDROLASE AS A TARGET FOR OCULAR DISEASES
  申请人：Indiana University Research and Technology Corporation

  公开号：US20210228539A1

  公开（公告）日：2021-07-29

  Methods of using compounds to inhibit ocular disease are disclosed herein. Methods are disclosed for inhibiting soluble epoxide hydrolase (sEH) for the treatment of ocular diseases, and in particular, wet age-related macular degeneration (AMD).
• [EN] COMPOSITION FOR BLOCKING ANGIOGENESIS<br/>[FR] COMPOSITION DE BLOCAGE DE L'ANGIOGENÈSE
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2017091473A1

  公开（公告）日：2017-06-01

  Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.