1-(3,5-bis(trifluoromethyl)phenyl)-2-nitroethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,5-bis(trifluoromethyl)phenyl)-2-nitroethanol
• 英文别名: 1-(3,5-Bis(trifluoromethyl)phenyl)-2-nitroethanol；1-[3,5-bis(trifluoromethyl)phenyl]-2-nitroethanol
• 化学式: C₁₀H₇F₆NO₃
• 分子量: 303.161
• InChiKey: GQHBMTRDLKWTKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  硝基甲烷 、 3,5-双三氟甲基苯甲醛 在 C₄₀H₄₉AgN₅O₈S₂⁽¹⁺⁾*BF₄^(1-) 、 caesium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以66%的产率得到1-(3,5-bis(trifluoromethyl)phenyl)-2-nitroethanol
  参考文献：
  名称：

  Silver comes into play: Henry reaction and domino cycloisomerisation sequence catalysed by [Ag(i)(Pc-L)] complexes

  摘要：

  含有活性下垂臂的吡啶配体的Ag(i)络合物是一种旧反应的新催化剂：硝基醛醇缩合反应。当底物为2-炔基芳基醛时，智能级联环异构化过程可能发生。

  DOI：

  10.1039/c6ra22231e

文献信息

• [EN] PHARMACEUTICAL COMPOUNDS AND DERIVATIVES<br/>[FR] COMPOSÉS PHARMACEUTIQUES ET DÉRIVÉS
  申请人：PFIZER PROD INC

  公开号：WO2009027785A2

  公开（公告）日：2009-03-05

  Pharmaceutical compounds according to Formula I and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans. Formula (I) or a pharmaceutically acceptable salt of said compound; wherein Formula (II) M and J are each independently CH2 or a bond wherein at least one of M and J are CH2.
• Silver comes into play: Henry reaction and domino cycloisomerisation sequence catalysed by [Ag(<scp>i</scp>)(Pc-L)] complexes
  作者：Giorgio Tseberlidis、Monica Dell'Acqua、Daniele Valcarenghi、Emma Gallo、Elisabetta Rossi、Giorgio Abbiati、Alessandro Caselli

  DOI：10.1039/c6ra22231e

  日期：——

  The Ag(i) complexes of pyridine-containing ligands with an active pendant arm are new catalysts for an old reaction: the nitroaldol condensation. When the substrates are 2-alkynylarylaldehydes, a smart cascade cycloisomerisation process can occur.

  含有活性下垂臂的吡啶配体的Ag(i)络合物是一种旧反应的新催化剂：硝基醛醇缩合反应。当底物为2-炔基芳基醛时，智能级联环异构化过程可能发生。