ethyl 4-(2-chlorophenylthio)-3-oxobutanoate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: ethyl 4-(2-chlorophenylthio)-3-oxobutanoate
• 英文别名: Ethyl 4-(2-chlorophenyl)sulfanyl-3-oxobutanoate
• 化学式: C₁₂H₁₃ClO₃S
• mdl: MFCD19382892
• 分子量: 272.752
• InChiKey: WUISPHSZMJAEOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(2-chlorophenylthio)-3-oxobutanoate 在 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 3-O-ethyl 5-O-methyl (2Z,3S,4R)-2-[(2-chlorophenyl)sulfinylmethylidene]-6-methyl-4-[2-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-3,5-dicarboxylate
  参考文献：
  名称：

  5-氰基-1,4-二氢-6-甲基-2-[[（苯磺酰基）甲基] -4-芳基-3-吡啶-羧酸乙酯和类似物的钙通道阻滞和正性肌力活性。合成和结构活性关系。

  摘要：

  描述了一系列2-[（（芳基磺酰基）甲基] -4-芳基-5-氰基-1,4-二氢吡啶-3-羧酸酯和类似物的合成和药理学评价。这些化合物具有独特的特性，即钙通道阻滞和体外正性肌力活性。选择化合物54作为该系列中最好的化合物，并进行了详细研究。还报道了54种对映异构体的合成和生物学特征。数据表明，尽管54的钙通道阻滞特性是立体定向的，但正性肌力活性不是。描述和评价了3-和6-氰基和其他紧密相关的1,4-二氢吡啶衍生物的实例以进行比较，发现它们没有上述双重活性。

  DOI：

  10.1021/jm00111a047
• 作为产物：
  描述：

  邻氯苯硫酚 、 4-氯乙酰乙酸乙酯 在 三乙胺 作用下， 反应 4.0h， 生成 ethyl 4-(2-chlorophenylthio)-3-oxobutanoate
  参考文献：
  名称：

  5-氰基-1,4-二氢-6-甲基-2-[[（苯磺酰基）甲基] -4-芳基-3-吡啶-羧酸乙酯和类似物的钙通道阻滞和正性肌力活性。合成和结构活性关系。

  摘要：

  描述了一系列2-[（（芳基磺酰基）甲基] -4-芳基-5-氰基-1,4-二氢吡啶-3-羧酸酯和类似物的合成和药理学评价。这些化合物具有独特的特性，即钙通道阻滞和体外正性肌力活性。选择化合物54作为该系列中最好的化合物，并进行了详细研究。还报道了54种对映异构体的合成和生物学特征。数据表明，尽管54的钙通道阻滞特性是立体定向的，但正性肌力活性不是。描述和评价了3-和6-氰基和其他紧密相关的1,4-二氢吡啶衍生物的实例以进行比较，发现它们没有上述双重活性。

  DOI：

  10.1021/jm00111a047

文献信息

• Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis
  作者：Tian Chen、Radhia Benmohamed、Anthony C. Arvanites、Hantamalala Ralay Ranaivo、Richard I. Morimoto、Robert J. Ferrante、D. Martin Watterson、Donald R. Kirsch、Richard B. Silverman

  DOI：10.1016/j.bmc.2010.10.052

  日期：2011.1

  Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assay expressing mutant G93A SOD1, two bioactive chemical hit compounds (1 and 2), identified as arylsulfanyl pyrazolones, were identified. The structural optimization of this scaffold led to the generation of a more potent analogue (19) with an EC50 of 170 nM. To determine the suitability of this class of compounds for further optimization, 1 was subjected to a battery of pharmacokinetic assays; most of the properties of 1 were good for a screening hit, except it had a relatively rapid clearance and short microsomal half-life stability. Compound 2 was found to be blood-brain barrier penetrating with a brain/plasma ratio = 0.19. The optimization of this class of compounds could produce novel therapeutic candidates for ALS patients. (C) 2010 Elsevier Ltd. All rights reserved.
• Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyridinecarboxylate and analogs. Synthesis and structure-activity relationships
  作者：Ila Sircar、Eva K. Gregor、K. R. Anderson、Stehen J. Haleen、Yu Hsin Shih、Ronald E. Weishaar、Robert P. Steffen、Thomas A. Pugsley、M. D. Taylor

  DOI：10.1021/jm00111a047

  日期：1991.7

  The synthesis and pharmacological evaluation of a series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogues are described. These compounds possess a unique profile namely, calcium channel blocking and positive inotropic activities in vitro. Compound 54 was selected as the best compound in the series and was studied in detail. The synthesis and biological

  描述了一系列2-[（（芳基磺酰基）甲基] -4-芳基-5-氰基-1,4-二氢吡啶-3-羧酸酯和类似物的合成和药理学评价。这些化合物具有独特的特性，即钙通道阻滞和体外正性肌力活性。选择化合物54作为该系列中最好的化合物，并进行了详细研究。还报道了54种对映异构体的合成和生物学特征。数据表明，尽管54的钙通道阻滞特性是立体定向的，但正性肌力活性不是。描述和评价了3-和6-氰基和其他紧密相关的1,4-二氢吡啶衍生物的实例以进行比较，发现它们没有上述双重活性。
• Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition
  作者：Antonella Peduto、Verena Krauth、Selene Collarile、Fiederike Dehm、Marika Ambruosi、Carmela Belardo、Francesca Guida、Antonio Massa、Veronica Esposito、Sabatino Maione、Mario de Rosa、Oliver Werz、Rosanna Filosa

  DOI：10.1016/j.ejmech.2015.11.048

  日期：2016.1

  Following the results we previously reported on a series of ethyl 2-phenylthiomethyl 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase (5-LOX) inhibitors, in order to obtain a more selective compound with respect to the previous generation of derivatives, we decided to modify the structure of the core ligand.The first level of structural modification involved the annelation of benzene to the indole, yielding corresponding benzo[g]indole derivatives, systematic optimization of methyl or chlorine groups in meta, ortho- and ortho/para-position of 2-phenylthiomethyl moiety were applied. The reported results show that extension of the aromatic core led to a great enhancement of activity, especially in cell-free assay, and the accurate structure-based design provided compounds 6f, 6g and 61 that block 5-LOX activity in cell-free assays with IC50 ranging from 0.17 to 0.22 mu M, and suppress 5-LOX product synthesis in polymorphonuclear leukocytes with IC50 ranging from 0.19 to 0.37 mu M. Moreover we have identified 6f and 61 as dual 5-lipoxygenase (5-LO) and microsomal prostaglandin E-2 synthase-1 (mPGES-1) inhibitors and compound 61 significantly reduces inflammatory reactions in the carrageenan-induced mouse paw oedema. The reported in vivo analysis, together with the accessible synthetic procedure, stimulate for the generation of further potent antinflammatory benzoindoles-based agents. (C) 2015 Published by Elsevier Masson SAS.