AcTyr-Arg-Gly-Asp-Val-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AcTyr-Arg-Gly-Asp-Val-OH
• 英文别名: Ac-Tyr-Arg-Gly-Asp-Val-OH；(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
• 化学式: C₂₈H₄₂N₈O₁₀
• 分子量: 650.689
• InChiKey: BYNCOGDUJOUNTH-MXBUBSDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  46
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  305
• 氢给体数：
  10
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  N-苄氧羰基-L-酪氨酸 、 AcTyr-Arg-Gly-Asp-Val-OH 在 双氧水 、 horseradish peroxidase 作用下， 以 various solvent(s) 为溶剂， 反应 0.75h， 以26%的产率得到
  参考文献：
  名称：

  Oxidative phenol coupling—tyrosine dimers and libraries containing tyrosyl peptide dimers

  摘要：

  The principles of phenol oxidation are outlined and summarized. Various procedures were used to dimerize tyrosine derivatives, especially linear tripeptides and cyclohexapeptides, via cross-linking of their phenolic side-chains. The coupling was performed by potassium hexacyanoferrate(III), phenyliodine(III)-bis(trifluoroacetate), vanadium(V)-oxyfluoride or horseradish peroxidase. The individual dityrosine and isodityrosine derivatives obtained in preparative scale, as well as the peptide-dimer libraries generated, were characterized by HPLC and electrospray ionization mass spectrometry. Further analyses were carried out by NMR spectroscopy, fluorescence spectroscopy and gas chromatography. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00942-x

文献信息

• Oxidative phenol coupling—tyrosine dimers and libraries containing tyrosyl peptide dimers
  作者：Holger Eickhoff、Günther Jung、Anton Rieker

  DOI：10.1016/s0040-4020(00)00942-x

  日期：2001.1

  The principles of phenol oxidation are outlined and summarized. Various procedures were used to dimerize tyrosine derivatives, especially linear tripeptides and cyclohexapeptides, via cross-linking of their phenolic side-chains. The coupling was performed by potassium hexacyanoferrate(III), phenyliodine(III)-bis(trifluoroacetate), vanadium(V)-oxyfluoride or horseradish peroxidase. The individual dityrosine and isodityrosine derivatives obtained in preparative scale, as well as the peptide-dimer libraries generated, were characterized by HPLC and electrospray ionization mass spectrometry. Further analyses were carried out by NMR spectroscopy, fluorescence spectroscopy and gas chromatography. (C) 2000 Elsevier Science Ltd. All rights reserved.