((5-methoxypentyloxy)methyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ((5-methoxypentyloxy)methyl)benzene
• 英文别名: 5-benzyloxy-1-methoxy-pentane；5-methoxypentoxymethylbenzene
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: FICPBZWMLJEKAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ((5-methoxypentyloxy)methyl)benzene 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以100%的产率得到5-甲氧基-1-戊醇
  参考文献：
  名称：

  WO2008/79382

  摘要：

  公开号：
• 作为产物：
  描述：

  5-苄氧基-1-戊醇 、 碘甲烷 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 以70%的产率得到((5-methoxypentyloxy)methyl)benzene
  参考文献：
  名称：

  2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS

  摘要：

  公开号：

  EP1124810B9

文献信息

• PROTEIN-PROTEIN INTERACTION INDUCING TECHNOLOGY
  申请人：Arvinas, Inc.

  公开号：US20170281784A1

  公开（公告）日：2017-10-05

  The present disclosure is based on the surprising and unexpected discovery that a ligand molecule with certain characteristics is able to bind to two protein molecules simultaneously and recruit them to form a transient or stable protein-protein interaction complex. The protein-protein interaction and other cross-domain interactions gained in this process contribute additional stabilization energy to the complex beyond the combination of the binary binding energies, and therefore, largely increase the binding potency of the ligand. Accordingly, the present disclosure provides a Protein-Protein Interaction Inducing Technology (PPIIT), which includes a method to design and identify the tripartite or bifunctional compounds and use such compounds to induce protein-protein interactions in various contexts. The present disclosure also provides a composition for the purpose of inducing protein-protein interactions.

  本公开基于一个惊人且意想不到的发现，即具有特定特征的配体分子能够同时结合两个蛋白质分子，并招募它们形成瞬时或稳定的蛋白质-蛋白质相互作用复合物。在这个过程中获得的蛋白质-蛋白质相互作用和其他跨领域相互作用为复合物提供了额外的稳定能量，超越了二元结合能的组合，因此大大增加了配体的结合效能。因此，本公开提供了一种蛋白质-蛋白质相互作用诱导技术（PPIIT），其中包括一种设计和识别三部分或双功能化合物的方法，并使用这些化合物在各种情境中诱导蛋白质-蛋白质相互作用。本公开还提供了一种用于诱导蛋白质-蛋白质相互作用的组合物。
• Unusual o-alkylation with iodomethyltrimethylsilane
  作者：T. K. Chakraborty、G. V. Reddy

  DOI：10.1039/c39890000251

  日期：——

  Iodomethyltrimethylsilane alkylates alkoxide ions giving rise to O-methyl and O-trimethylsilyl ethers which are formed by cleavage of the silicon–carbon bond.

  碘甲基三甲基硅烷烷基化烷氧基离子，生成O-甲基和O-三甲基甲硅烷基醚，它们是通过硅碳键断裂形成的。
• Sphingosine-1-phosphate receptor agonist and antagonist compounds
  申请人：Wallace Grier A.

  公开号：US20090029947A1

  公开（公告）日：2009-01-29

  The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

  本发明涉及一种新型、有效和选择性的药剂，它们是S1P受体家族中一个或多个单个受体的激动剂或拮抗剂。本发明的化合物可用作治疗与S1P受体家族中单个受体的激动或拮抗有关的医学状况的治疗剂。
• 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents
  申请人：Pharmacia & Upjohn S.p.A.

  公开号：US07037929B1

  公开（公告）日：2006-05-02

  Compounds which are 2-amino-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group, optionally further substituted, selected from i) straight or branched C1–C8 alkyl, C2–C6 alkenyl or C2–C6 alkynyl; ii) C3–C6 cycloalkyl; iii) aryl or arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; R1 is an optionally further substituted group selected from: i) straight or branched C1–C8 alkyl or C2–C6 alkenyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; v) arylalkenyl with from 2 to 6 carbon atoms within the straight or branched alkenyl chain; vi) an optionally protected amino acid residue; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.

  公式（I）的2-氨基-1,3-噻唑衍生物化合物，其中R是卤素原子、硝基、可选择取代的氨基基团或是选择自i)直链或支链C1-C8烷基、C2-C6烯基或C2-C6炔基的基团，可选地进一步取代；ii)C3-C6环烷基；iii)芳基或芳基烷基，其在直链或支链烷基链内有1至8个碳原子；R1是可选择进一步取代的基团，包括i)直链或支链C1-C8烷基或C2-C6烯基；ii)3至6成员的碳环或5至7成员的杂环；iii)芳基或芳基羰基；iv)芳基烷基，其在直链或支链烷基链内有1至8个碳原子；v)芳基烯基，其在直链或支链烯基链内有2至6个碳原子；vi)可选择保护的氨基酸残基；或其药学上可接受的盐；可用于治疗与细胞依赖性激酶活性改变相关的细胞增殖性疾病。
• Compounds and methods for the targeted degradation of androgen receptor
  申请人：Arvinas, Inc.

  公开号：US11352351B2

  公开（公告）日：2022-06-07

  The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.

  本发明涉及双功能化合物，可用于降解和（抑制）雄激素受体。特别是，本发明涉及的化合物一端含有与泛素连接酶结合的 VHL 配体，另一端含有与雄激素受体结合的分子，从而使雄激素受体靠近泛素连接酶，以实现对雄激素受体的降解（和抑制）。本发明显示了与根据本发明的化合物相关的广泛药理活性，与雄激素受体的降解/抑制一致。