呋喃-2-羧酸 (4-羟基苯基)酰胺 | 4104-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 呋喃-2-羧酸 (4-羟基苯基)酰胺
• 中文别名: 呋喃-2-羧酸（4-羟基-苯基）-酰胺
• 英文名称: N-(4-hydroxyphenyl)furan-2-carboxamide
• 英文别名: Brenzschleimsaeure-p-hydroxyanilid
• CAS: 4104-33-0
• 化学式: C₁₁H₉NO₃
• mdl: MFCD00033635
• 分子量: 203.197
• InChiKey: DGVKXCATWIGAIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2932190090

反应信息

• 作为反应物：
  描述：

  呋喃-2-羧酸 (4-羟基苯基)酰胺 在 三乙胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 N-{4-[2-hydroxy-3-(piperidin-1-yl)propoxy]phenyl}furan-2-carboxamide
  参考文献：
  名称：

  10.1002/cbdv.202400948

  摘要：

  Due to its severe damage, Spodoptera frugiperda is receiving attention as one of the biggest dangers to world food security. Although there are numerous insecticides that are widely and successfully used to control S. frugiperda, they do not have an immediate effect. In our work focusing for synthesized twelve novel benzamide derivatives and examined their insecticidal effectiveness against S. frugiperda larvae in their second & fourth larvae instars, with the aim of further improving the insecticidal activity based on combination principles. Several spectroscopic methods, including elemental analysis, NMR & infrared spectroscopy, were employed for confirming the structure of the newly designed products. It has been discovered that most compounds show good of promising efficacy. With an LC50 of 24.8 mg/L for larvae in the second instar & 56.2 mg/L for larvae in the fourth instar, compound 23 was the most active. Among all compounds 11, 22 and 20 exhibited excellent results. Furthermore, a number of biological and histopathological properties of the demonstration compounds of the produced goods under laboratory conditions were also examined. This work further demonstrates the anti‐proliferation of S. frugiperda and offers fresh ideas for the manufacture of benzamide derivatives.

  DOI：

  10.1002/cbdv.202400948
• 作为产物：
  描述：

  呋喃甲酰氯 、 对氨基苯酚 在 N,N-二异丙基乙胺 作用下， 以 水 为溶剂， 以36%的产率得到呋喃-2-羧酸 (4-羟基苯基)酰胺
  参考文献：
  名称：

  在TPGS-750-M水溶液中通过酰氯简单地合成酰胺

  摘要：

  通过酰基氯与胺在2 wt％TPGS-750-M水溶液中的反应，将表面活性剂化学技术用于酰胺键的构建。特别是，这种高效的方法可以实现无色谱的可扩展过程，并可以回收TPGS-750-M解决方案。

  DOI：

  10.1021/acs.oprd.0c00303

文献信息

• Modulators of peroxisome proliferator activated receptors
  申请人：Brooks Alisa Dawn

  公开号：US20050020684A1

  公开（公告）日：2005-01-27

  Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R 1 and W, R 2 is (CH 2 ) n —CH(OR 2 )—(CH 2 ) n E, —(CH)═C(OR 2 )—(CH 2 ) n E, —(CH 2 ) n —CH(Y)—(CH 2 ) m E or (CH)═C(Y)(CH 2 ) m E; wherein E is COOR 3 , C 1 -C 3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C 1 -C 6 alkyl, haloalkyl and aryl-C o - 4 -alkyl; R 2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR 4 , —COOR 4 , —CONR 5 R 6 , —C(S)R 4 , —C(S)OR 4 or C(S)NR 5 R 6 , R 3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH 2 —, CH 2 CH 2 — or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R 1 . R 4 -R 6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

  本发明公开了一种由结构式（I）表示的化合物：其中Ar是取代或未取代的芳香基团。Q是共价键，-CH2-或-CH2CH2-; W是取代或未取代的烷基或取代或未取代的异烷基连接基，长度为两到十个原子，优选长度为两到七个原子。苯环A可选地与R1和W以外的最多四个取代基取代，R2是（CH2）n-CH（OR2）-（CH2）nE，-（CH）=C（OR2）-（CH2）nE，-（CH2）n-CH（Y）-（CH2）mE或（CH）=C（Y）（CH2）mE;其中E是COOR3，C1-C3烷基腈，羧酰胺，磺酰胺，酰基磺酰胺或四唑，磺酰胺，酰基磺酰胺和四唑可选地与一个或多个取代基取代，独立地选自：C1-C6烷基，卤代烷基和芳基-Co-4-烷基; R2是H，脂肪基，取代脂肪基，卤代烷基，芳基，取代芳基，-COR4，-COOR4，-CONR5R6，-C（S）R4，-C（S）OR4或C（S）NR5R6，R3是H，脂肪基，取代脂肪基，芳基或取代芳基。Y是O-，CH2-，CH2CH2-或CH═CH-，并与Phenyl环A中与R1相邻的碳原子键合。R4-R6独立地是H，脂肪基，取代脂肪基，芳基或取代芳基。n和m独立地为0、1或2。
• HEAT-SENSITIVE SUBLIMATION TRANSFER CYAN DYE AND TRANSFER SHEET
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0443045A1

  公开（公告）日：1991-08-28

  A heat-sensitive sublimation transfer cyan dye represented by general formula (I), wherein R₁ is a hydrogen atom, an alkyl group, an alkoxy group, an alkylcarbonylamino group, a formylamino group or a halogen atom and R₂ and R₃ are each an alkyl group, an alkenyl group, an alkoxyalkyl group, an aralkyl group, an aryl group, a halogenoalkyl group or a cyanoalkyl group, provided that they may be combined to each other to form a ring, and X is any one of groups (a), (b) and (c), and a heat-sensitive sublimation transfer sheet comprising at least one of said dyes.

  一种由通式(I)表示的热敏升华转移青色染料，其中 R₁ 是氢原子、烷基、烷氧基、烷基羰基氨基、甲酰基氨基或卤原子，R₂ 和 R₃ 各自是烷基、烯基、烷氧基烷基、芳基、卤代烷基或氰基烷基，但它们可以相互结合成环、烷氧基烷基、芳基、芳烷基、卤代烷基或氰基烷基，但它们可相互结合形成环，且 X 为 (a)、(b) 和 (c) 组中的任一组，以及包含至少一种所述染料的热敏升华转印片材。
• AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1442041A1

  公开（公告）日：2004-08-04
• US5183474A
  申请人：——

  公开号：US5183474A

  公开（公告）日：1993-02-02
• [EN] AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSES HETEROARYLES SUBSTITUES AZABICYCLIQUES POUR LE TRAITEMENT DE MALADIES
  申请人：UPJOHN CO

  公开号：WO2003040147A1

  公开（公告）日：2003-05-15

  The invention provides compounds of Formula (I): Azabicyclo-N(R1)-C(=X)-W These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals in which α7 is known to be involved.