2-methyl-2-n-pentyl-3,3-di(p-methylphenyl)-4-cyano-5-amino-2,3-dihydrofuran

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-2-n-pentyl-3,3-di(p-methylphenyl)-4-cyano-5-amino-2,3-dihydrofuran
• 英文别名: 2-methyl-2-n-pentyl-3,3-di(4-methyl-)phenyl-4-cyano-5-amino-2,3-dihydrofuran；2-Amino-5-methyl-4,4-bis(4-methylphenyl)-5-pentylfuran-3-carbonitrile
• 化学式: C₂₅H₃₀N₂O
• 分子量: 374.526
• InChiKey: RXQFQJMZQHMVLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-庚酮 、 dicyanomethylene-4,4'-dimethylbenzophenone 在 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到2-methyl-2-n-pentyl-3,3-di(p-methylphenyl)-4-cyano-5-amino-2,3-dihydrofuran
  参考文献：
  名称：

  Facile Synthesis of Polysubstituted 2,3-Dihydrofuran and Cyclopentenylamine Derivatives Promoted by Samarium Diiodide

  摘要：

  The intermolecular reductive coupling of 1,1-diaryl-2,2-dicyanoethylenes or 1,1-diaryl-2-cyano-2-ethoxycarbonylethylenes with ketones or chalcones induced by samarium (II) iodide was studied. Functionalized 2,3-dihydrofuran and cyclopentenylamine derivatives were prepared in moderate to good yields under neutral and mild conditions.

  DOI：

  10.1081/scc-120021985

文献信息

• Facile Synthesis of Polysubstituted 2,3-Dihydrofuran and Cyclopentenylamine Derivatives Promoted by Samarium Diiodide
  作者：Xiaoliang Xu、Yongmin Zhang

  DOI：10.1081/scc-120021985

  日期：2003.1.8

  The intermolecular reductive coupling of 1,1-diaryl-2,2-dicyanoethylenes or 1,1-diaryl-2-cyano-2-ethoxycarbonylethylenes with ketones or chalcones induced by samarium (II) iodide was studied. Functionalized 2,3-dihydrofuran and cyclopentenylamine derivatives were prepared in moderate to good yields under neutral and mild conditions.
• Liu, Yongjun; Zhang, Yongmin, Journal of Chemical Research, Miniprint, 2003, # 6, p. 621 - 635
  作者：Liu, Yongjun、Zhang, Yongmin

  DOI：——

  日期：——