5-(pyridin-2-ylmethyloxy)-3-methylthio-1,2,4-thiadiazole

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(pyridin-2-ylmethyloxy)-3-methylthio-1,2,4-thiadiazole
• 英文别名: 5-(2-pyridylmethyloxy)-3-methylthio-1,2,4-thiadiazole；3-methylsulfanyl-5-(pyridin-2-ylmethoxy)-1,2,4-thiadiazole
• 化学式: C₉H₉N₃OS₂
• 分子量: 239.322
• InChiKey: HLXGLXBIHXNIMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-吡啶甲醇 、 5-氯-3-(甲硫基)-1,2,4-噻二唑 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 2.75h， 生成 5-(pyridin-2-ylmethyloxy)-3-methylthio-1,2,4-thiadiazole
  参考文献：
  名称：

  EP1475374

  摘要：

  公开号：

文献信息

• Methods for treating an inflammatory condition or inhibiting JNK
  申请人：——

  公开号：US20040127536A1

  公开（公告）日：2004-07-01

  This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  这项发明通常涉及吲唑衍生物，具有以下结构： 1 或药用可接受的盐，其中R 1 ，R 2 和A如本文所述定义。这类化合物在治疗对JNK抑制剂有响应的广泛疾病和障碍，如炎症性疾病或障碍中具有用途。因此，还披露了治疗这些疾病和障碍的方法，以及包含一个或多个上述化合物的药物组合物。
• Indazole compounds, compositions thereof and methods of treatment therewith
  申请人：Bhagwat S. Shripad

  公开号：US20050009876A1

  公开（公告）日：2005-01-13

  This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

  这项发明通常涉及使用吲唑化合物来治疗或预防与蛋白激酶相关的疾病，包括酪氨酸激酶，诸如增殖性疾病、炎症性疾病、异常血管生成及其相关疾病、动脉硬化、黄斑变性、糖尿病、肥胖、疼痛等。这些方法包括向有需要的患者施用有效量的吲唑化合物，以抑制、调节或控制酪氨酸激酶信号转导。本文中提供了一种新型的吲唑化合物或其药用可接受的盐。
• Indazole derivatives as JNK inhibitors and compositions and methods related thereto
  申请人：——

  公开号：US20020103229A1

  公开（公告）日：2002-08-01

  Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: 1 wherein R 1 , R 2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  本发明公开了作为JNK选择性抑制剂的化合物。本发明的化合物是吲唑衍生物，具有以下结构： 1 其中R 1 ，R 2 和A如本文所述定义。此类化合物在治疗对JNK抑制产生响应的广泛病症方面具有用途。因此，还公开了治疗此类病症的方法，以及包含一个或多个上述化合物的药物组合物。
• Thiadiazole compounds and use thereof
  申请人：Ihara Hideki

  公开号：US20050215578A1

  公开（公告）日：2005-09-29

  A thiadiazole compound of the formula (A): wherein R 1 represents methyl, C3-C7 alkenyl, C2-C7 alkoxyalkyl, C2-C7 alkylthioalkyl, C4-C7 alkoxyalkoxyalkyl, C4-C7 alkylthioalkoxyalkyl, phenyl C1-C2 alkyl in which phenyl may be substituted, phenyloxy C1-C2 alkyl in which phenyloxy may be substituted, phenyl C2-C3 alkoxyalkyl in which phenyl may be substituted, or the substituent of the formula (B): wherein R represents C1-C3 alkyl, and R 4 represents a hydrogen atom, methyl, ethyl or phenyl which may be substituted; and R 2 represents phenyl C1-C4 alkyl in which phenyl may be substituted, pyridyl C1-C4 alkyl in which pyridyl may be substituted, or pyrimidyl C1-C4 alkyl in which pyrimidyl may be substituted; has an excellent arthropod pests controlling activity.

  式（A）的噻二唑化合物，其中 R1代表甲基，C3-C7烯基，C2-C7烷氧基烷基，C2-C7烷硫基烷基，C4-C7烷氧基烷氧基烷基，C4-C7烷硫基烷氧基烷基，苯基C1-C2烷基，其中苯基可以被取代，苯氧基C1-C2烷基，其中苯氧基可以被取代，苯基C2-C3烷氧基烷基，其中苯基可以被取代，或式（B）的取代基：其中R代表C1-C3烷基，R4代表氢原子，甲基，乙基或苯基，可以被取代；而R2代表苯基C1-C4烷基，其中苯基可以被取代，吡啶基C1-C4烷基，其中吡啶基可以被取代，或嘧啶基C1-C4烷基，其中嘧啶基可以被取代；具有优异的节肢动物害虫控制活性。
• Methods for treating, preventing and managing chronic lymphocytic leukemia with indazole compounds
  申请人：Bennett Brydon

  公开号：US20070060616A1

  公开（公告）日：2007-03-15

  This invention is generally directed to the use of Indazole Compounds for treating or preventing chronic lymphocytic leukemia. The methods comprise the treatment or prevention of chronic lymphocytic leukemia comprising administering an effective amount of an indazole compound, or a pharmaceutically acceptable salt or composition thereof, to a patient in need thereof.

  这项发明通常是针对使用吲唑类化合物治疗或预防慢性淋巴细胞白血病。该方法包括向需要治疗或预防慢性淋巴细胞白血病的患者给予有效量的吲唑类化合物，或其药学上可接受的盐或组合物。