2-ethyl-5,6-dihydro-2,5,5-trimethyl-2H-1,3-oxazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环化合物
• 英文名称: 2-ethyl-5,6-dihydro-2,5,5-trimethyl-2H-1,3-oxazine
• 英文别名: 2-ethyl-2,5,5-trimethyl-6H-[1,3]oxazine；2-ethyl-2,5,5-trimethyl-6H-1,3-oxazine
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: ULMHHDOZIUEYJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-二甲基-3-羟基丙醛 、 丁酮 在 氨 作用下， 以 氯仿 为溶剂， 反应 18.0h， 以16%的产率得到2-ethyl-5,6-dihydro-2,5,5-trimethyl-2H-1,3-oxazine
  参考文献：
  名称：

  A new 5,6-dihydro-2H-1,3-oxazine synthesis via Asigner-type condensation

  摘要：

  In this article - which we dedicate to the lifework1 of Professor Teruaki Mukaiyama - a new general 5,6-dihydro-2H-1,3-oxazine synthesis is described. 3-Hydroxy-2,2-dimethylpropionaldehyde is condensed with a second oxo component and ammonia to the title compound in several examples. In the case of citronellal diastereoselectivity is observed.

  DOI：

  10.1016/s0040-4020(01)80219-2

文献信息

• A new 5,6-dihydro-2H-1,3-oxazine synthesis via Asigner-type condensation
  作者：Alexander Dömling、Ivar K. Ugi

  DOI：10.1016/s0040-4020(01)80219-2

  日期：——

  In this article - which we dedicate to the lifework1 of Professor Teruaki Mukaiyama - a new general 5,6-dihydro-2H-1,3-oxazine synthesis is described. 3-Hydroxy-2,2-dimethylpropionaldehyde is condensed with a second oxo component and ammonia to the title compound in several examples. In the case of citronellal diastereoselectivity is observed.