N-(4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-(4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenyl)acetamide
• 英文别名: N-{4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenyl}acetamide；N-{4-(1h-phenanthro[9,10-d]imidazol-2-yl)phenyl}-acetamide；N-[4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenyl]acetamide
• 化学式: C₂₃H₁₇N₃O
• 分子量: 351.407
• InChiKey: YRLUGQRRHKJMCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对乙酰氨基苯甲醛 、 菲醌 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 以86%的产率得到N-(4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenyl)acetamide
  参考文献：
  名称：

  磁性纳米粒子上固定化的Preyssler杂多酸的制备，表征及应用作为绿色和可回收的合成咪唑的催化剂

  摘要：

  通过将Preyssler杂多酸（HPA）固定在涂有羟基磷灰石（HA）的Ni 0.5 Zn 0.5 Fe 2 O 4磁铁矿纳米颗粒（MNPs）上，合成了一种高效的磁可分离催化剂。通过扫描电子显微镜（SEM），透射电子显微镜（TEM），X射线衍射（XRD），FT-IR，能量色散谱（EDS）和TGA对催化剂进行表征。在室温下，无溶剂条件下，通过[9,10]-菲蒽醌与芳基醛和乙酸铵的一锅三组分缩合，在咪唑衍生物的合成中测试了该催化剂的活性。

  DOI：

  10.1134/s1070363217120453

文献信息

• Preparation, Characterization, and Application of Preyssler Heteropoly Acid Immobilized on Magnetic Nanoparticles as a Green and Recoverable Catalyst for the Synthesis of Imidazoles
  作者：A. Javid、A. Khojastehnezhad、A. J. L. Pombeiro

  DOI：10.1134/s1070363217120453

  日期：2017.12

  magnetically separable catalyst was synthesized by immobilization of Preyssler heteropoly acid (HPA) on Ni0.5Zn0.5Fe2O4 magnetite nanoparticles (MNPs) coated with hydroxyapatite (HA). The catalyst was characterized by scaning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), FT-IR, energy dispersive spectroscopy (EDS), and TGA. Activity of this catalyst was tested in

  通过将Preyssler杂多酸（HPA）固定在涂有羟基磷灰石（HA）的Ni 0.5 Zn 0.5 Fe 2 O 4磁铁矿纳米颗粒（MNPs）上，合成了一种高效的磁可分离催化剂。通过扫描电子显微镜（SEM），透射电子显微镜（TEM），X射线衍射（XRD），FT-IR，能量色散谱（EDS）和TGA对催化剂进行表征。在室温下，无溶剂条件下，通过[9,10]-菲蒽醌与芳基醛和乙酸铵的一锅三组分缩合，在咪唑衍生物的合成中测试了该催化剂的活性。
• Aryl imidazoles and their use as anti-cancer agents
  申请人：Huesca Mario

  公开号：US20070123553A1

  公开（公告）日：2007-05-31

  Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
• ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS
  申请人：Aptose Biosciences Inc.

  公开号：US20150374669A1

  公开（公告）日：2015-12-31

  Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
• US8969372B2
  申请人：——

  公开号：US8969372B2

  公开（公告）日：2015-03-03
• Efficientone-pot synthesis of imidazoles catalyzed by silica-supported La0.5Pb0.5MnO3 nano particles as anovel and reusable perovskite oxide
  作者：N. Zahedi、A. Javid、M. K. Mohammadi、H. Tavakkoli

  DOI：10.4314/bcse.v32i1.15

  日期：——

  Silica-supported La0.5Pb0.5MnO3 nanoparticles was prepared and used as a new perovskite-type catalyst for rapid and efficient synthesis of substituted imidazoles by an one-pot three-component condensation of [9,10]-phenanthraquinone, aryl aldehydes and ammonium acetate in excellent yield under reflux, and also solvent-free conditions.

  制备了二氧化硅支撑的 La0.5Pb0.5MnO3 纳米粒子，并将其用作一种新的过氧化物型催化剂，用于在回流和无溶剂条件下，通过[9,10]-菲醌、芳基醛和乙酸铵的单锅三组分缩合反应，快速高效地合成取代的咪唑类化合物。