1-diphenylmethyl-1-hydroxy-2-methyl-3-butanone (anti)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-diphenylmethyl-1-hydroxy-2-methyl-3-butanone (anti)
• 英文别名: (3S,4S)-4-hydroxy-3-methyl-5,5-diphenylpentan-2-one
• 化学式: C₁₈H₂₀O₂
• 分子量: 268.356
• InChiKey: IVEPGEQBARPLSX-FZKQIMNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-丁烯-2-醇 、 联苯乙醛 在 tris(triphenylphosphine)ruthenium(II) chloride 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate 作用下， 反应 2.0h， 生成 1-diphenylmethyl-1-hydroxy-2-methyl-3-butanone (anti) 、
  参考文献：
  名称：

  Aldol- and Mannich-Type Reactions via in Situ Olefin Migration in Ionic Liquid

  摘要：

  [GRAPHICS]An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)(3) was developed with ionic liquid as the solvent. The solvent/caltalyst system could be reused for at least five times with no loss of reactivity.

  DOI：

  10.1021/ol0273102

文献信息

• Aldol- and Mannich-Type Reactions via in Situ Olefin Migration in Ionic Liquid
  作者：Xiao-Fan Yang、Mingwen Wang、Rajender S. Varma、Chao-Jun Li

  DOI：10.1021/ol0273102

  日期：2003.3.1

  [GRAPHICS]An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)(3) was developed with ionic liquid as the solvent. The solvent/caltalyst system could be reused for at least five times with no loss of reactivity.