(Z)-N-(3-acetyl-3-methyl-4-oxo-1-phenylpent-1-en-1-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-N-(3-acetyl-3-methyl-4-oxo-1-phenylpent-1-en-1-yl)acetamide
• 英文别名: N-[(Z)-3-acetyl-3-methyl-4-oxo-1-phenylpent-1-enyl]acetamide
• 化学式: C₁₆H₁₉NO₃
• 分子量: 273.332
• InChiKey: CGHOCBLOJMWZHZ-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙酮肟 在 copper(l) iodide 、 manganese(III) triacetate dihydrate 、 碳酸氢钠 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 6.0h， 生成 (Z)-N-(3-acetyl-3-methyl-4-oxo-1-phenylpent-1-en-1-yl)acetamide
  参考文献：
  名称：

  Direct Oxidative Coupling of Enamides and 1,3-Dicarbonyl Compounds: A Facile and Versatile Approach to Dihydrofurans, Furans, Pyrroles, and Dicarbonyl Enamides

  摘要：

  An efficient manganese(III)-mediated oxidative coupling reaction between a-aryl enamides and 1,3-dicarbonyl compounds has been developed. A series of dihydrofurans and dicarbonyl enamides were synthesized in moderate to good yields. Moreover, these dihydrofurans could be readily transformed into the corresponding furans and pyrroles via the Paal-Knorr reaction.

  DOI：

  10.1021/ol503009f

文献信息

• Direct Oxidative Coupling of Enamides and 1,3-Dicarbonyl Compounds: A Facile and Versatile Approach to Dihydrofurans, Furans, Pyrroles, and Dicarbonyl Enamides
  作者：Pan Li、Jingjing Zhao、Chungu Xia、Fuwei Li

  DOI：10.1021/ol503009f

  日期：2014.11.21

  An efficient manganese(III)-mediated oxidative coupling reaction between a-aryl enamides and 1,3-dicarbonyl compounds has been developed. A series of dihydrofurans and dicarbonyl enamides were synthesized in moderate to good yields. Moreover, these dihydrofurans could be readily transformed into the corresponding furans and pyrroles via the Paal-Knorr reaction.