7-<(3S)-3-amino-1-pyrrolidynyl>-1-(2-fluoro-4-hydroxyphenyl)-6-fluoro-1,4-dihydro-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-<(3S)-3-amino-1-pyrrolidynyl>-1-(2-fluoro-4-hydroxyphenyl)-6-fluoro-1,4-dihydro-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 英文别名: 7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1-(2-fluoro-4-hydroxyphenyl)-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 化学式: C₂₀H₁₈F₂N₄O₄
• 分子量: 416.384
• InChiKey: NHGLJNJSTXNLRX-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3-氟苯酚 在 palladium on activated charcoal sodium nitrate 、 硫酸 、 氢溴酸 、 氢气 、 potassium carbonate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醇 、 溶剂黄146 、 乙腈 为溶剂， 反应 4.0h， 生成 7-<(3S)-3-amino-1-pyrrolidynyl>-1-(2-fluoro-4-hydroxyphenyl)-6-fluoro-1,4-dihydro-5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and Biological Activity of Novel N-1-Aryl-6-fluoro-5-methyl 1,8-Naphthyridine-3-carboxylic Acids

  摘要：

  A series of 5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids was prepared in which the N-1 position was substituted by various aryl groups. Seven compounds showed excellent in vitro antibacterial activity against Gram-positive and Gram-negative strains.

  DOI：

  10.3987/com-92-6121

文献信息

• Synthesis and Biological Activity of Novel N-1-Aryl-6-fluoro-5-methyl 1,8-Naphthyridine-3-carboxylic Acids
  作者：Jean-Pierre Jacquet、Daniel Bouzard、Pierre Di Cesare、Nicolas Dolnic、Massoud Massoudi、Philippe Remuzon

  DOI：10.3987/com-92-6121

  日期：——

  A series of 5-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acids was prepared in which the N-1 position was substituted by various aryl groups. Seven compounds showed excellent in vitro antibacterial activity against Gram-positive and Gram-negative strains.